How and Why Macrophages are Connected with the Parkinson’s Disease: A Short Review to Develop a Therapeutic Strategy for PD

Abstract

Chronic neuro-inflammation cause the neural cell death including dopaminergic cells and ultimate results Parkinson’s disease (PD). In an MPTP-induced PD animal model an increased peripheral pro-inflammatory M1 macrophages (M1- MFs) were found. Polarization of this M1-type of MFs to anti-inflammatory M2-type revealed a potential therapeutic benefit for PD patients. Here we highlight the concept of MFs re-education as a method of PD therapies, and how we can deploy our knowledge to find out therapeutic regimen for PD treatment.