Serum Neopterin in Differential Diagnosis of Bacterial Diarrhea in Pediatric Patients

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2019-01-01 DOI:10.1515/pteridines-2019-0011

K. Plata-Nazar, G. Łuczak, A. Liberek, Katarzyna Sznurkowska, B. Kamińska, A. Szlagatys-Sidorkiewicz

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引用次数: 1

Abstract

Abstract Background: Neopterin, regarded as a marker of cellular immune activation, has been used in diagnosis of infection caused by intracellular pathogens. We have aimed to evaluate the clinical usefulness of serum neopterin (NPT) in acute bacterial diarrhea caused by group C enteropathogenic Escherichia coli (EPECs) and group D Salmonella spp. Methods: Serum concentration of NPT was determined by ELISA. The study group included 47 children with diagnosis of bacterial diarrhea: 32 caused by group C enteropathogenic Escherichia coli (EPECs) and 15 by group D Salmonella spp. 105 healthy children constituted the control group. Results: Serum concentration of NPT in children infected with group D Salmonella spp. turned out to be higher than in the other groups. The fraction of Salmonella-infected patients with serum neopterin above 11 nmol/l proved higher as compared to children with diarrhea caused by group C EPECs or to the healthy controls. The prevalence of a C-reactive protein (CRP) to NPT ratio of greater than 1 did not differ significantly between children with diarrhea of various etiology. Conclusions: Neopterin can be used as a non-specific marker differentiating between bacterial diarrhea of various etiology.

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血清新蝶呤在小儿细菌性腹泻中的鉴别诊断价值

摘要背景：新蝶呤作为细胞免疫激活的标志物，已被用于诊断细胞内病原体引起的感染。我们旨在评估血清新蝶呤（NPT）在C组肠致病性大肠杆菌（EPEC）和D组沙门氏菌引起的急性细菌性腹泻中的临床应用。研究组包括47名被诊断为细菌性腹泻的儿童：32名由C组肠致病性大肠杆菌引起，15名由D组沙门氏菌引起。105名健康儿童组成对照组。结果：感染D组沙门氏菌的儿童血清NPT浓度明显高于其他组。与C组EPEC引起的腹泻儿童或健康对照组相比，血清新蝶呤高于11nmol/l的沙门氏菌感染患者的比例被证明更高。不同病因腹泻儿童的C反应蛋白（CRP）与NPT比值大于1的患病率没有显著差异。结论：新蝶呤可作为鉴别各种病因细菌性腹泻的非特异性标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.