Evaluation of the Relationship Between Thrombolytic Treatment Complications and Laboratory Parameters in Acute Ischemic Stroke Patients

Abstract

Objective: We aimed to investigate the role of serum uric acid and lactate levels and mean platelet volume in predicting treatment success in patients with ischemic stroke. Methods: One hundred and five patients who were diagnosed with cerebrovascular disease and received thrombolytic or thrombectomy treatment were included in the study. Patients were divided into two groups as patients who developed complications and who did not develop complications. Demographical characteristics, laboratory findings, the National Institutes of Health Stroke Scale (NIHSS) scores at admission and at discharge, and Modified Rankin Scale (mRS) score were investigated retrospectively. Results: Of all patients, 58.1% of the were male. There were no differences in terms of laboratory parameters between the groups. NIHSS score at admission, NIHSS score at discharge, and mRS score were significantly higher in the group that developed complications after treatment (p<0.05). Laboratory values did not differ significantly between the groups. Early mortality rate in the group which developed complications was significantly higher than the group which did not develop complications (p<0.05). Univariate model revealed significant effectiveness of NIHSS score at admission and at discharge, and mRS score in the differentiation of patients with and without complications (p<0.05). In the multivariate model, a significant and independent effectiveness of the NIHSS score at discharge was observed in the differentiation of patients with and without complications (sensitivity =83.3%, positive prediction =30.8%, specificity =57.1% and negative prediction =93.8%; p<0.05). Conclusion: We found no significant associations between the development of complications after thrombolytic therapy and laboratory findings. The NIHSS score may be a suitable parameter in predicting complications. Evaluation of the Relationship Between Thrombolytic Treatment Complications and Laboratory Parameters in Acute Ischemic Stroke Patients.