Confirmation of the Rabbit Hemorrhagic Disease Virus Type 2 (GI.2) Circulation in North Africa

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Acta Veterinaria-Beograd Pub Date : 2022-12-01 DOI:10.2478/acve-2022-0035

Aissa Saidi, Abdelouahed Aboutaib

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Abstract

Abstract Rabbit hemorrhagic disease (RHD) is a highly contagious viral disease that causes fatal acute hepatitis in domestic and wild lagomorphs. It has taken on major economic importance in countries like Morocco. In addition to the classical virus (RHDV), a novel emerged genotype (RHDV2) is circulating, especially in the north shore of the Mediterranean basin since 2010. Many small animal farmers reported clinical cases from several rabbitries in Agadir (Morocco) despite systematic vaccination against the RHDV. The main objective was to characterize the current RHDV strains circulating in the studied area to help to choose an adequate vaccine. For that, we extracted viral RNA from rabbit livers, carried out the PCR analyses, and we sequenced the viral structural capsid protein (VP60) of the RHDV. The phylogenetic analysis results allowed us to state that the novel genotype (RHDV2) is circulating in the studied geographical area, and to characterize the isolated sequences. As a conclusion, we recommend updating RHD epidemiological relating data and reviewing the vaccine protocols by both targeting RHDV (GI.1) and RHDV2 (GI.2) in any future preventive program.

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兔出血性疾病病毒2型(GI.2)在北非流行的确认

兔出血性疾病(RHD)是一种在家兔和野生兔中引起致死性急性肝炎的高传染性病毒性疾病。它在摩洛哥等国家具有重要的经济意义。除了经典病毒(rhdvv)外，一种新出现的基因型(RHDV2)自2010年以来正在流行，特别是在地中海盆地北岸。尽管有系统地接种了狂犬病疫苗，但在Agadir(摩洛哥)，许多小动物养殖户报告了几只兔子的临床病例。主要目的是表征目前在研究地区流行的RHDV毒株，以帮助选择适当的疫苗。为此，我们从兔肝中提取病毒RNA，进行PCR分析，并对RHDV的病毒结构衣壳蛋白(VP60)进行测序。系统发育分析结果使我们能够确定新基因型(RHDV2)在所研究的地理区域流行，并对分离序列进行了表征。作为结论，我们建议更新RHD流行病学相关数据，并在未来的任何预防计划中审查针对RHDV (GI.1)和RHDV2 (GI.2)的疫苗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Veterinaria-Beograd 农林科学-兽医学

CiteScore

1.30

自引率

16.70%

发文量

审稿时长

18-36 weeks

期刊介绍： The Acta Veterinaria is an open access, peer-reviewed scientific journal of the Faculty of Veterinary Medicine, University of Belgrade, Serbia, dedicated to the publication of original research articles, invited review articles, and to limited extent methodology articles and case reports. The journal considers articles on all aspects of veterinary science and medicine, including the diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.