Correlation between the levels of plasma brain natriuretic peptide and coxsackie virus A6 in hand, foot and mouth disease

中国小儿急救医学 Pub Date : 2020-01-20 DOI:10.3760/CMA.J.ISSN.1673-4912.2020.01.010

He Song, Yufeng Zhang, H. Deng, Jun Wang, Pengfei Xu, Juan Yuan, Ruiqing Liu, T. Tang

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Abstract

Objective To investigate the clinical value of plasma brain natriuretic peptide (BNP) levels in predicting the severity of hand, foot and mouth disease (HFMD) in children with coxsackie virus A6 (CV-A6) infection. Methods A total of 305 children with CV-A6 type HFMD admitted to Xi′an Children′s Hospital from January 2017 to December 2018 were divided into general group (200 cases) and severe group (105 cases) according to the severity of the disease.The receiver operating characteristic curve was used to calculate the value of plasma BNP levels to predict the severe CV-A6 HFMD.Multivariate logistic regression analysis was used to analyze the correlation between the related factors and the severity of CV-A6 HFMD. Results Compared with the normal group, children in the severe group had statistically significant differences in WBC level, BNP level, neurological symptoms, circulatory disorders, and blood glucose levels(all P 15×109/L, blood glucose> 8.3 mmol/L, and BNP>294.85 ng/L were related to the severity of CV-A6 HFMD(OR=2.275, P=0.013; OR=6.057, P=0.028; OR=1.008, P<0.001). Conclusion BNP>294.85 ng/L is closely related to the severity of CV-A6 HFMD and has predictive value.It is an early warning factor for the severity of CV-A6 HFMD. Key words: Hand, foot and mouth disease; Coxsackie virus A6; Brain natriuretic peptide; Risk factors

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手足口病患者血浆脑钠肽水平与柯萨奇病毒A6的相关性

目的探讨血浆脑钠肽（BNP）水平在预测儿童柯萨奇病毒A6（CV-A6）感染手足口病（HFMD）严重程度中的临床价值。方法2017年1月至2018年12月Xi市儿童医院收治的305例CV-A6型手足口病患儿，根据病情严重程度分为一般组（200例）和重症组（105例）。采用受试者操作特征曲线计算血浆BNP水平值，预测严重CV-A6型手足口病。采用多元逻辑回归分析相关因素与CV-A6手足口病严重程度的相关性。结果重症组患儿WBC、BNP水平、神经系统症状、循环系统疾病、，血糖水平（P均为15×109/L，血糖＞8.3mmol/L，BNP＞294.85ng/L）与CV-A6 HFMD的严重程度有关（OR=2.275，P=0.013；OR=6.057，P=0.028；OR=1.008，P294.85 ng/L与CV-A6手足口病的严重程度密切相关，具有预测价值。是CV-A6 HFMD严重程度的预警因素。关键词：手足口病；柯萨奇病毒A6；脑钠肽；危险因素

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来源期刊

中国小儿急救医学

自引率

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发文量

6226

期刊介绍： Chinese Journal of Neurology was established in 1955, the predecessor of which is Chinese Journal of Neurology and Psychiatry. Chinese Journal of Neurology and Psychiatry has been indexed by MEDLINE until 1996, when it was divided into two journals, Chinese Journal of Neurology, and Chinese Journal of Psychiatry. Chinese Journal of Neurology is now indexed by EM, SCOPUS, AJ, WPRIM, CNKI, Wanfang Data, CSCD, etc. The impact factor of the journal is 2.755 in 2017, ranking the first among all neurological and psychological journals in China and among all the 142 medical journals published by the Chinese Medical Association. The journal is available both in print and online.