Association of NLRP2 gene polymorphisms with type 1 diabetes mellitus in Chinese Han population

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1000-6699.2020.02.004

Xiaoxiao Sun, Ying Xia, Linling Xu, S. Luo, Jian Lin, Yang Xiao, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou

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Abstract

Objective To evaluate the association between NLRP2(NLR Family Pyrin Domain Containing 2) gene polymorphisms and classical type 1 diabetes mellitus(T1DM) in Chinese Han population. Methods A case-control study was conducted in 510 classical T1DM patients from the Department of Metabolism and Endocrinology in the Second Xiangya Hospital affiliated to Central South University and 531 healthy controls in this region. The polymorphisms of rs1043673 in NLRP2 gene were analyzed by MassARRAY. Mann-Whitney U test and χ2 test were used to compare the differences between patients and controls. Logistic regression analysis and χ2 test were performed to compare the distributions of the alleles and genotypes between T1DM patients and controls. Kruskal-Wallis H test was used to compare the clinical characteristics of different genotypes in T1D patients. Results The differences of the allele and genotype distributions in rs1043673 of NLRP2 gene were not significant between patients and controls. The polymorphisms of rs1043673 were associated with fasting C-peptide(P=0.029), postprandial 2-h C-peptide(P=0.017), and titer of GADA(P=0.043) in T1DM patients. Conclusion The polymorphisms of NLRP2 gene were associated with the characteristics of T1DM patients. Key words: Diabetes mellitus, type 1; NLRP2 gene; Polymorphism, single nucleotide

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中国汉族人群NLRP2基因多态性与1型糖尿病的关系

目的探讨中国汉族人群NLRP2基因多态性与典型1型糖尿病（T1DM）的关系。方法采用病例对照研究方法，对中南大学附属湘雅二医院代谢内分泌学科510例T1DM患者和531名健康对照者进行研究。应用MassARRAY分析了NLRP2基因rs1043673的多态性。Mann-Whitney U检验和χ2检验用于比较患者和对照组之间的差异。采用Logistic回归分析和χ2检验比较T1DM患者和对照组等位基因和基因型的分布。Kruskal-Wallis H检验用于比较T1D患者不同基因型的临床特征。结果NLRP2基因rs1043673等位基因和基因型分布在患者和对照组之间无显著差异。rs1043673多态性与T1DM患者的空腹C肽（P=0.029）、餐后2小时C肽（P=0.017）和GADA滴度（P=0.043）相关。结论NLRP2基因多态性与T1DM患者的临床特征有关。关键词：糖尿病，1型；NLRP2基因；多态性，单核苷酸

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.