Effectiveness of Chitosan versus Collagen Membrane for Wound Healing in Maxillofacial Soft Tissue Defects: A Comparative Clinical Study

Q4 Medicine
A. Haque, K. Ranganath, K. Prasad, S. Munoyath, R. M. Lalitha
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引用次数: 1

Abstract

Wound healing is a specific biological process related to the general phenomenon of growth and tissue regeneration [1]. The variety of wound types has resulted in a wide range of wound dressing materials with new products frequently introduced to target different aspects of the wound healing process. Wound dressings and devices form an important segment of the medical and pharmaceutical market. The ideal dressing should achieve rapid healing at reasonable cost with minimal inconvenience to the patient. In the past, traditional dressings such as natural or synthetic bandages, cotton wool, lint and gauzes all with varying degrees of absorbency were used for the management of wounds. Modern dressings are based on the concept of creating an optimum environment to allow epithelial cells to move unimpeded, for the treatment of wounds. Such optimum conditions include a moist environment around the wound, effective oxygen circulation to aid regenerating cells and tissues and a low bacterial load [2]. It is important therefore, that different dressings be evaluated and Received 6 August 2019 Accepted 30 September 2019 Published online 31 March 2020 Chitosan has been shown to act as an effective hemostat and antimicrobial agent with additional aid in wound healing. The purpose of this study was to compare the wound healing properties of Chitosan versus a more established material like Collagen in a clinical controlled trial. A study conducted at our institution, encompassed all the patients with facial soft tissue abrasions, from July 2016 to July 2017. They were randomly divided into two groups, half treated with Chitosan membrane and the other half treated with Collagen. Comparisons were made according to the pain, time taken for granulation tissue formation and scarring. Sixty patients were included in the study. It was observed that pain reduction over a week was significantly higher in the Collagen group than in the Chitosan group. Significant results in favor of Chitosan were found with regard to average time taken for granulation tissue formation and pigmentation of the resultant scars. The results indicate that Chitosan enhances soft tissue healing, improves color matching and minimizes scarring, as compared to Collagen. Chitosan in its non-resorbable form, however required multiple dressing changes. Chitosan membrane can be an alternative to Collagen membrane as a facial wound dressing material.
壳聚糖与胶原膜修复颌面部软组织缺损创面的临床比较研究
伤口愈合是一个特定的生物学过程,与生长和组织再生的普遍现象有关[1]。伤口类型的多样性产生了广泛的伤口敷料材料,新产品经常被引入,以针对伤口愈合过程的不同方面。伤口敷料和器械是医疗和制药市场的重要组成部分。理想的敷料应以合理的成本实现快速愈合,并将给患者带来的不便降至最低。过去,传统的敷料,如天然或合成绷带、棉絮、皮棉和纱布,都具有不同程度的吸收性,用于伤口管理。现代敷料的理念是创造一个最佳的环境,让上皮细胞不受阻碍地移动,以治疗伤口。这种最佳条件包括伤口周围的潮湿环境、帮助细胞和组织再生的有效氧气循环以及低细菌负荷[2]。因此,重要的是,评估不同的敷料并于2019年8月6日收到2019年9月30日接受2020年3月31日在线发布壳聚糖已被证明是一种有效的止血剂和抗菌剂,对伤口愈合有额外的帮助。本研究的目的是在临床对照试验中比较壳聚糖与胶原蛋白等更成熟的材料的伤口愈合特性。我们机构进行的一项研究涵盖了2016年7月至2017年7月期间所有面部软组织擦伤的患者。他们被随机分为两组,一半用壳聚糖膜处理,另一半用胶原蛋白处理。根据疼痛、肉芽组织形成所需的时间和疤痕进行比较。60名患者被纳入研究。观察到胶原蛋白组在一周内的疼痛减轻显著高于壳聚糖组。在肉芽组织形成和所得疤痕色素沉着所需的平均时间方面,发现了有利于壳聚糖的显著结果。结果表明,与胶原蛋白相比,壳聚糖能增强软组织愈合,改善配色,最大限度地减少疤痕。然而,不可吸收形式的壳聚糖需要多次换药。壳聚糖膜可以替代胶原膜作为面部伤口敷料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Biomaterials and Artificial Organs
Trends in Biomaterials and Artificial Organs Medicine-Medicine (miscellaneous)
CiteScore
0.70
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