Serum Neopterin Levels and IDO Activity as Possible Markers for Presence and Progression of Hepatitis B

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2020-01-01 DOI:10.1515/pteridines-2020-0010

D. Koc, Y. Özhan, E. Acar, Nilgun Bireroglu, F. Aslan, Murat Keğin, H. Sipahi

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引用次数: 3

Abstract

Abstract Chronic Hepatitis B virus (HBV) is still one of the major reasons for liver related mortality and morbidity all around the world. This study aimed to investigate the possible relationship between the immune system activation and presence, as well as progression, of hepatitis B infection by monitoring the tryptophan degradation and serum neopterin levels in patients with HBV. 110 patients with HBV and 23 healthy subjects were included in the study. The patients had significantly higher neopterin levels and increased kynurenine to tryptophan ratios, which were most probably due to enhanced indoleamine 2,3-dioxygenase (IDO) activity compared to healthy control. A strong positive correlation was found between neopterin levels and IDO activity in patient group. Neopterin levels and IDO activity were markedly increased in patients with histological activity index (HAI) ≥4 compared to HAI<4, and a significant correlation was found between neopterin and HAI. Moreover, there was a significant correlation between albumin levels and IDO activity in HBV patients. These findings suggest that tryptophan degradation results from IFN-γ-induced IDO activation, likewise depletion of albumin synthesis in HBV patients may result from diminished tryptophan availability. In conclusion, based on the study results, serum neopterin levels and IDO activity could provide additional immunological information for monitoring liver histological activity and can be used as prognostic markers in HBV disease.

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血清新蝶呤水平和IDO活性作为乙型肝炎存在和进展的可能标志物

摘要慢性乙型肝炎病毒（HBV）仍然是世界各地肝相关死亡和发病的主要原因之一。本研究旨在通过监测HBV患者的色氨酸降解和血清新蝶呤水平，探讨免疫系统激活与乙型肝炎感染的存在和进展之间的可能关系。110名HBV患者和23名健康受试者被纳入研究。与健康对照组相比，患者的新蝶呤水平显著升高，犬尿氨酸与色氨酸的比例增加，这很可能是由于吲哚胺2，3-双加氧酶（IDO）活性增强。患者组新蝶呤水平与IDO活性呈正相关。组织活性指数（HAI）≥4的患者的新蝶呤水平和IDO活性显著高于组织活性指数<4的患者，并且新蝶呤与HAI之间存在显著相关性。此外，HBV患者的白蛋白水平与IDO活性之间存在显著相关性。这些发现表明，色氨酸降解是由IFN-γ诱导的IDO激活引起的，同样，HBV患者白蛋白合成的减少可能是由色氨酸可用性降低引起的。总之，根据研究结果，血清新蝶呤水平和IDO活性可以为监测肝脏组织学活性提供额外的免疫信息，并可作为HBV疾病的预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.