Neurofibromatosis Type 1 with Arnold Chiari Type 1 Malformation in A Child

Abstract

Neurocutaneous disorders primarily affect the central and peripheral nervous systems, as well as the skin, and can ultimately lead to the development of tumors in these organs. Neurofibromatosis type 1 (NF1) is one of the most common neurocutaneous syndromes, with a reported incidence of approximately 1 in 2,600 to 1 in 3,000 individuals [1]. It is an autosomal dominant genetic disorder caused by pathogenic variants of the NF1 tumor suppressor gene located on chro-mosome 17q11.2