Expressions of miR-132, miR-145 and miR-208 in Patients with Acute Myocardial Infarction and Correlations with Gensini Score

Abstract

The researchers aimed to investigate the correlations of miR-132, miR-145 and miR-208 with the Gensini score (GS) of patients with acute myocardial infarction (AMI). Totally 120 AMI patients and 80 healthy volunteers undergoing physical examination were included into AMI group and healthy group, respectively. The AMI patients were subdivided into low GS (LGS) group (< 30 points) and high GS (HGS) group (>30 points). Independent risk factors included troponin I (TnI), creatine kinase (CK) isoenzyme, uric acid (UA), C-reactive protein (CRP), miR-132, miR-145 and miR208, which affected the severity of coronary artery lesions (CALs) (P<0.05). Compared with miR-132, miR-145, and miR208 alone, their combination had the highest diagnostic value, with the area under curve (95%CI) of 0.911 (0.869-0.978), sensitivity of 89.89 percent and specificity of 70.91 percent (P<0.001). MiR-132, miR-145, and miR-208 are abnormally expressed in AMI patients. Their combination has higher diagnostic value for the severity of CALs in AMI patients.