Exploring the Potential of Honey and Curcumin as Antidepressent

Abstract

| Depression is a common psychiatric disorder which is characterized by mood swings, aversion from activity and apathy which affects the thoughts, behavior and feelings of wellbeing. Honey and curcumin, traditional folk medicines, are thought to steadfast the defense mechanisms of body against oxidative stress which is a key factor in elevating depression. This study is designed to reveal the efficacy of honey and curcumin against depression in rat model. 24 male wister rats were randomly divided into 4 groups. After the trial, blood biochemistry was done in which antioxidant enzymes like SOD, Catalyze, Glutathione peroxidase were performed that shows significantly high levels in the blood than the group that was treated with nicotine and shows a positive correlation with the days at which the rat’s groups were given a supplemented feed. Total antioxidant capacity and antioxidative stress shows significant results by the selected treatment. Article History Received: September 24, 2018 Revised: March 10, 2019 Accepted: June 03, 2019 Published: June 26, 2019 Authors’ Contributions MNS identified the research area, prepared and conducted the research. HR and KA assisted in provision of research material. MNR helped in experiments and writing the manuscript. MRT assisten in designing the project. AM helped in sampling.