Natural Compound Isoliensinine Inhibits Stress-Induced Hair Greying by Blocking β2-Adrenoceptor

IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Lingchen Yan, Miaomiao Li, Meidi Zhu, Ruishuang Sun, Ying Gao, Xiaojing Zhao, Yuanqiang Ling, X. Xu, Weiwei Chu, Xusheng Wang
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引用次数: 0

Abstract

Chronic and acute stress caused by emotional or physical insults can affect the function of other organs via the brain-body axis. As one of the smallest organs in mammalian, hair follicles are highly susceptible to stress. Under stress, the sympathetic nerves release norepinephrine (NA), which acts directly on the β-2 adrenergic receptors on melanocyte stem cells (MeSCs) within the hair follicles, causing the MeSCs to lose quiescence and enter a rapid proliferation state followed by differentiation and migration, leading to rapid loss of MeSCs and, ultimately, grey hair. Here, we screened out β-2 blockers forming the ZINC 15 compound database, found a natural product isoliensinine, and was effective in preventing stress-induced hair greying in mice. The study sheds light on the development of products that use natural compounds to prevent stress-induced hair greying.
天然化合物异连肌氨酸通过阻断β2-肾上腺素受体抑制压力诱导的头发变白
由情绪或身体上的侮辱引起的慢性和急性应激可通过脑-体轴影响其他器官的功能。毛囊是哺乳动物体内最小的器官之一,对压力非常敏感。在应激状态下,交感神经释放去甲肾上腺素(NA), NA直接作用于毛囊内黑素细胞干细胞(MeSCs)上的β-2肾上腺素能受体,使MeSCs失去静止状态,进入快速增殖状态,继而分化和迁移,导致MeSCs迅速丧失,最终导致头发变白。在这里,我们筛选了β-2阻滞剂形成锌15化合物数据库,发现一种天然产物异连体氨酸,有效地防止应激性小鼠头发变白。这项研究揭示了使用天然化合物来防止压力引起的头发变白的产品的开发。
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来源期刊
CiteScore
4.10
自引率
5.00%
发文量
226
审稿时长
6 months
期刊介绍: The Journal of Clinical Pharmacy and Therapeutics provides a forum for clinicians, pharmacists and pharmacologists to explore and report on issues of common interest. Reports and commentaries on current issues in medical and pharmaceutical practice are encouraged. Papers on evidence-based clinical practice and multidisciplinary collaborative work are particularly welcome. Regular sections in the journal include: editorials, commentaries, reviews (including systematic overviews and meta-analyses), original research and reports, and book reviews. Its scope embraces all aspects of clinical drug development and therapeutics, including: Rational therapeutics Evidence-based practice Safety, cost-effectiveness and clinical efficacy of drugs Drug interactions Clinical impact of drug formulations Pharmacogenetics Personalised, stratified and translational medicine Clinical pharmacokinetics.
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