Radial percolation reveals that Cancer Stem Cells are trapped in the core of colonies

IF 1.2 Q3 PHYSICS, MULTIDISCIPLINARY

Papers in Physics Pub Date : 2021-04-09 DOI:10.4279/PIP.130002

L. Barberis

引用次数: 1

Abstract

Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be confined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.

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放射状渗滤显示癌症干细胞被困在集落的核心

利用几何论点，表明癌症干细胞（CSCs）必须在自然条件下限制在实体瘤内。在基于代理的模型和渗流理论的帮助下，估计了CSC位于群体边界的概率。该概率被估计为CSC自我更新概率ps的函数；即CSC在有丝分裂后保持未分化的机会。在最常见的情况下，ps是低的，并且大多数CSC以非常低的速率产生分化的细胞。本文的结果表明，CSC在癌症细胞集落的中心形成小核心；由于缺乏繁殖空间，它们变得静止不动，这稳定了它们的种群规模。这一结果为CSC生态位大小提供了一个简单的解释，省去了对群体感应或其他提出的信号机制的需要。这也支持了转移可能在肿瘤发展的最开始就开始的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Papers in Physics PHYSICS, MULTIDISCIPLINARY-

CiteScore

1.90

自引率

0.00%

发文量

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