Scavenging Activity on Reactive Oxygen Species with Biological Relevance by Varronia curassavica

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Orbital: The Electronic Journal of Chemistry Pub Date : 2023-07-15 DOI:10.17807/orbital.v15i2.17939

G. Brasil, Romão Veloso, R. P. Assis, Juhan Augusto, Scardelato Pereira, Alexandre Carvalho, C. P. Soares, I. L. Brunetti, V. Isaac, Paulo Ricelli, G. Zocolo, M. Correa, André Gonzaga, dos Santos

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Abstract

Varronia curassavica Jacq. is a medicinal plant found in Brazil used as anti-inflammatory. Here, we investigated the in vitro antioxidant activity of 70 % ethanol extract of V. curassavica leaves on synthetic radicals (ABTS•+/DPPH•) and reactive oxygen species (O2•-, ROO•, HOCl/OCl-, H2O2), besides its in vitro cytotoxicity. The extract was characterized by UPLC-ESI-QToF-MSE and the annotated compounds were one hydroxybenzoic acid, five phenylpropanoids, and three glycosylated quercetin derivatives, being the main compound rosmarinic acid or its isomer. The antioxidant activity was very promising in all tests, highlighting on the capture of O2•-, which EC50 value was three times lower than Trolox. This activity may be due to the presence of the major compounds, all phenolic compounds. The extract also presented low cytotoxicity. Thus, the extract from V. curassavica leaves has great potential as an antioxidant.

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curassavica对具有生物学相关性的活性氧的清除活性

杰克。是一种在巴西发现的药用植物，用于消炎。本文研究了curassavica叶片70%乙醇提取物对合成自由基(ABTS•+/DPPH•)和活性氧(O2•-、ROO•、HOCl/OCl-、H2O2)的体外抗氧化活性及其体外细胞毒性。经UPLC-ESI-QToF-MSE表征，化合物为1个羟基苯甲酸、5个苯丙素和3个糖基化槲皮素衍生物，主要化合物为迷迭香酸或其异构体。在所有测试中，其抗氧化活性都很有希望，特别是对O2•-的捕获，其EC50值比Trolox低3倍。这种活性可能是由于主要化合物的存在，所有的酚类化合物。该提取物还具有较低的细胞毒性。因此，curassavica叶提取物具有很强的抗氧化潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orbital: The Electronic Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： Orbital: The Electronic Journal of Chemistry is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Original contributions (in English) are welcome, which focus on all areas of Chemistry and their interfaces with Pharmacy, Biology, and Physics. Neither authors nor readers have to pay fees. The journal has an editorial team of scientists drawn from regions throughout Brazil and world, ensuring high standards for the texts published. The following categories are available for contributions: 1. Full papers 2. Reviews 3. Papers on Education 4. History of Chemistry 5. Short communications 6. Technical notes 7. Letters to the Editor The Orbital journal also publishes a number of special issues in addition to the regular ones. The central objectives of Orbital are threefold: (i) to provide the general scientific community (at regional, Brazilian, and worldwide levels) with a formal channel for the communication and dissemination of the Chemistry-related literature output by publishing original papers based on solid research and by reporting contributions which further knowledge in the field; (ii) to provide the community with open, free access to the full content of the journal, and (iii) to constitute a valuable channel for the dissemination of Chemistry-related investigations.

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