"PREVENTIVE ANTENATAL INTERVENTIONS TO REDUCE PREMATURE BIRTHS"

Abstract

objective of our paper was to evaluate the role of antenatal interventions in preventing premature births and their complications. Our paper is a narrative review and we selected studies from PubMed database from January 2000 to January 2021 using the following Medical Subject Headings: The results of the studies show there is an improvement of fetal and maternal outcomes when certain drugs are used such as tocolytic agents, antibiotherapy or corticosteroids. Every class of drug we presented in our paper aim to reduce the mortality and morbidity of main role is to delay the delivery for at least 48 hours, to administrate antenatal corticosteroids for enhancing fetal lung maturity. Uterine contractions involve the interaction between actin and myosin with myometrial cells, medi-ated by myosin light-chain kinase 2,3 . The mechanism of action of tocolytic agents involves the regulation of the myosin light-chain kinase activity: calcium and cyclic adenosine monophosphate (AMP). Many agents are used to inhibit these contractions, including magnesium sulphate, calcium channel blockers, oxytocin antagonists, nonsteroidal an-ti-inflammatory drugs (NSAIDs) and beta-adrenergic receptor agonists. No evidence exists that tocolytic therapy has any direct favorable effect on neonatal outcomes or that any prolongation of pregnancy afforded by tocolytics is translated to significant médicaments notre article à réduire la mortalité et la morbidité des nouveau-nés et administrées de elles préviennent la plupart des issues im-probables. Les qui ces stratégies sont limitées en termes de nombre d’études publiées, cependant, toutes les études que nous incluses soutiennent l’administration de ces médicaments Mots-clés: prématurité, anténatal, tocolyse, antibiothérapie, corticothérapie. they the data that support these are limited in terms of the number of published studies, however, all the studies we included support the administration of tocolytic agents, and corticosteroids as well as vitamin