Serum free fatty acid levels and insulin resistance in patients undergoing one-anastomosis gastric bypass

IF 1.6 4区医学 Q2 SURGERY

Videosurgery and Other Miniinvasive Techniques Pub Date : 2021-07-13 DOI:10.5114/wiitm.2021.107754

I. Liakh, M. Proczko-Stepaniak, M. Śledziński, Adriana Mika

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引用次数: 3

Abstract

Introduction One anastomosis gastric bypass (OAGB) leads to improvement in glucose homeostasis; however, the mechanism of this beneficial effect is not fully understood. Increased serum free fatty acid (FFA) concentrations in obese subjects contribute to the development of insulin resistance and type 2 diabetes. Aim The authors hypothesized that improvement in glucose homeostasis after OAGB may be associated with a decrease in FFA concentration. Material and methods Serum FFA levels were measured by gas chromatography-mass spectrometry before and 3 months after OAGB and, for comparison, in patients who underwent laparoscopic sleeve gastrectomy (LSG). Serum insulin was assayed by immunoenzymatic method, and other parameters by standard laboratory methods. Results OAGB resulted in a large decrease in FFA levels and great improvement in insulin sensitivity. These effects in patients after LSG were less prominent. Conclusions Results suggest that decreased serum FFA levels after OAGB contribute to resolution of insulin sensitivity after this type of bariatric surgery.

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吻合口胃分流术患者血清游离脂肪酸水平与胰岛素抵抗

引言一次吻合胃旁路移植（OAGB）可改善葡萄糖稳态；然而，这种有益效果的机制尚不完全清楚。肥胖受试者血清游离脂肪酸（FFA）浓度的增加有助于胰岛素抵抗和2型糖尿病的发展。目的作者假设OAGB后葡萄糖稳态的改善可能与FFA浓度的降低有关。材料和方法通过气相色谱-质谱法测定OAGB前和OAGB后3个月的血清FFA水平，并与腹腔镜袖状胃切除术（LSG）患者进行比较。血清胰岛素采用免疫酶法测定，其他参数采用标准实验室法测定。结果OAGB可显著降低FFA水平，改善胰岛素敏感性。LSG后患者的这些影响不那么显著。结论结果表明，OAGB后血清FFA水平的降低有助于解决此类减肥手术后的胰岛素敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Videosurgery and Other Miniinvasive Techniques 医学-外科

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

12 weeks

期刊介绍： Videosurgery and other miniinvasive techniques serves as a forum for exchange of multidisciplinary experiences in fields such as: surgery, gynaecology, urology, gastroenterology, neurosurgery, ENT surgery, cardiac surgery, anaesthesiology and radiology, as well as other branches of medicine dealing with miniinvasive techniques.