Electroencephalogram and somatosensory evoked potential evaluation for good and poor neurological prognosis after cardiac arrest: a prospective multicenter cohort trial (ProNeCA)

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2019-05-01 DOI:10.2217/FNL-2018-0036

M. Scarpino, R. Carrai, F. Lolli, G. Lanzo, M. Spalletti, D. Audenino, C. Callegarin, M. Celani, M. Lombardi, A. Marrelli, O. Mecarelli, C. Minardi, F. Minicucci, L. Motti, L. Politini, F. Valzania, E. Vitelli, A. Peris, A. Amantini, A. Grippo

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引用次数: 6

Abstract

Aim: Hypoxic-ischemic-encephalopathy is a severe and frequent neurological complication of successful cardiopulmonary-resuscitation after cardiac arrest. Prognosticating neurological outcomes in patients with hypoxic-ischemic-encephalopathy is challenging and recent guidelines suggest a multimodal approach. Only few studies have analyzed the prognostic power of the association between instrumental tests and, in addition, most of them were monocentric, retrospective and evaluating only poor outcome. Methods/design: We designed a multicenter prospective cohort study to assessing the prognostic power of the association of electroencephalogram and somatosensory evoked potentials for the prediction of both poor and good neurological outcomes at different times after cardiac arrest. Discussion: The results of our study will provide a high level of evidence for the use of neurophysiological evaluation in the current clinical practice.

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一项前瞻性多中心队列试验(ProNeCA):对心脏骤停后神经系统预后好坏的脑电图和体感诱发电位评估

目的：缺氧缺血性脑病是心脏骤停后成功心肺复苏的一种严重且常见的神经系统并发症。缺氧缺血性脑病患者的神经系统预后具有挑战性，最近的指南建议采用多模式方法。只有少数研究分析了仪器测试之间相关性的预后能力，此外，大多数研究都是单中心的、回顾性的，仅评估较差的结果。方法/设计：我们设计了一项多中心前瞻性队列研究，评估脑电图和体感诱发电位在心脏骤停后不同时间预测不良和良好神经结果的预后能力。讨论：我们的研究结果将为神经生理学评估在当前临床实践中的应用提供高水平的证据。

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.