Long-term Outcome of Infants with Spina Bifida Through Assessment of the Prognostic Value of Hostile Bladder Parameters

Abstract

Spina bifida (SB) is a condition that may result in chronic kidney disease secondary to bladder dysfunction. Despite a worldwide varying incidence, 1-6 cases are seen in every 1000 live births (1). Several studies reported better results with pro-active management strategies. (2,3). Different urodynamic parameters or scoring systems were suggested to detect patients who are at risk of upper urinary tract damage (4–6). In 2016, the Centers for Disease Control and Prevention (CDC) published a management algorithm for SB ABS TRACT Aim: In 2016, the Centers for Disease Control and Prevention (CDC) published a management algorithm for spina bifida (SB) cases from birth and started collecting data prospectively. They designated risk factors from urodynamic studies as end filling pressure or detrusor leak point pressure (DLPP) ≥40 cmH2O or neurogenic detrusor overactivity (NDO) with detrusor sphincter dyssynergia (DSD), and named this type of bladder dysfunction as “hostile bladder” (HB). They recommended the immediate start of clean intermittent catheterization and anticholinergics in these patients. Having similar concerns on this patient population, we designed a retrospective study to identify and reveal long-term outcomes of SB patients with HB.