Enantiomeric Separation of Chiral Alcohols Using Novel Core-Shell Type Chiral Stationary Phase Coated with Helical Poly(diphenylacetylene) Derivative by High-Performance Liquid Chromatography

Abstract

Enantiomeric separation ability on high-performance liquid chromatography (HPLC) of novel chiral stationary phase (CSP) was evaluated. A chiral selector of the CSP investigated in this study (SUMICHIRALTM OA-SHELL P1) is one of helical poly(diphenylacetylene) derivatives which is coated on core-shell silica support. OA-SHELL P1 showed excellent chiral separation ability for a wide range of aromatic chiral alcohols and it was also effective for separation of some chiral carboxylic acids, ketones and lactones. It is considered to be a new option for enantiomeric separation of these chiral compounds. OA-SHELL P1 is used in normal phase mode with a mobile phase of simple composition and one of its features is easy method development. The analysis time is relatively short even with conventional HPLC system since a core-shell support with particle size of 2.6 μm is used.