COVID-19 Infection in a Patient with Common Variable Immunodeficiency: Experience with Favipiravir and Intravenous Immunoglobulin

IF 0.3 Q4 ALLERGY

Astim Allerji Immunoloji Pub Date : 2021-08-20 DOI:10.21911/aai.618

E. Emre, G. Tazegul

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Abstract

ABSTRACT Data regarding COVID-19 infection in patients with common variable immunodeficiency (CVID) are limited. Herein, we present a 28-year-old male patient with CVID admitted for intravenous immunoglobulin (IVIG) replacement with myalgia and a productive cough. A nasopharyngeal swab for the SARS CoV-2 polymerase chain reaction assay was positive. Chest computed tomography was consistent with COVID-19 pneumonia. The patient refused hospitalization and the applicable treatment for COVID-19. Although he was prescribed IVIG, he had a lapse in IVIG replacement due to supply problems. The patient was later brought to the emergency room due to the deterioration of his general condition with dyspnea, tachypnea, shortness of breath, cough, and fever five days after the initial presentation. He was treated with favipiravir and IVIG and had a positive outcome. Results of COVID-19 infection in CVID patients are diverse, possibly due to underlying genetic defects. Although our patient had an increased risk for severe disease due to CVID, a lapse in IVIG replacement, and obesity, he did not require intensive care or intubation. Further studies are needed to determine and develop treatment strategies for COVID-19 infection in patients diagnosed with CVID. Keywords: COVID-19, common variable immunodeficiency disorders, immunodeficiencies, immunoglobulin, convalescent plasma

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常见可变免疫缺陷患者的新冠肺炎感染：Favipiravir和静脉注射免疫球蛋白的经验

摘要关于常见变异性免疫缺陷（CVID）患者新冠肺炎感染的数据有限。在此，我们报告了一名28岁的男性CVID患者，他因肌痛和生产性咳嗽接受静脉注射免疫球蛋白（IVIG）替代治疗。鼻咽拭子检测严重急性呼吸系统综合征冠状病毒2型聚合酶链式反应呈阳性。胸部计算机断层扫描与新冠肺炎一致。患者拒绝接受新冠肺炎的住院治疗和适用治疗。尽管给他开了IVIG，但由于供应问题，他在更换IVIG时出现了失误。患者后来被送往急诊室，原因是其总体状况恶化，在首次出现症状五天后出现呼吸困难、呼吸急促、呼吸短促、咳嗽和发烧。他接受了法匹拉韦和IVIG治疗，结果呈阳性。CVID患者感染新冠肺炎的结果多种多样，可能是由于潜在的遗传缺陷。尽管我们的患者由于CVID、IVIG替代失败和肥胖而患严重疾病的风险增加，但他不需要重症监护或插管。需要进一步的研究来确定和制定诊断为CVID的患者感染新冠肺炎的治疗策略。关键词：新冠肺炎，常见变异性免疫缺陷疾病，免疫缺陷，免疫球蛋白，恢复期血浆

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Astim Allerji Immunoloji ALLERGY-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Asthma Allergy Immunology has been published three times a year in April, August and December as the official and periodical journal of the Turkish National Society of Allergy and Clinical Immunology since 2003. All articles published in the journal have been available online since 2003. A peer reviewed system is used in evaluation of the manuscripts submitted to Asthma Allergy Immunology. The official language of the journal is English. The aim of the journal is to present advances in the field of allergic diseases and clinical immunology to the readers. In accordance with this goal, manuscripts in the format of original research, review, case report, articles about clinical and practical applications and editorials, short report and letters to the editor about allergic diseases and clinical immunology are published in the journal. The target reader population of the Asthma Allergy Immunology includes specialists and residents of allergy and clinical immunology, pulmonology, internal medicine, pediatrics, dermatology and otolaryngology as well as physicians working in other fields of medicine interested in allergy and immunological diseases.