Dosimetric evaluation of field-in-field and sliding-window IMRT in endometrium cancer patients with a new approach for the conformity index

Q4 Health Professions
Alper Ozseven, E. Ozkan
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引用次数: 3

Abstract

Background: Purpose of the study is to evaluate field-in-field (FIF) and slidingwindow intensity modulated radiation therapy (SW-IMRT) treatment plans in terms of homogeneity index (HI), conformity index (CI) and normal tissue doses for organs at risk (OAR) in patients with endometrial carcinoma along with deriving a new expression for CI. Materials and Methods: Four different FIF plans with different MLC (multi-leaf collimator) margins and SW-IMRT plan were compared in 20 endometrial cancer patients who underwent adjuvant pelvic radiotherapy with 50.4 Gy in 28 fractions. Normal tissue doses were assessed for OAR from dose volume histograms (DVHs). HI and CI values were calculated according to the reports of International Commission on Radiation Units and Measurements (ICRU)-83, Radiation Therapy Oncology Group (RTOG) 1993 and ICRU-62. A new CI was developed and named CIOPT standing for optimized conformity index. Results: SW-IMRT provided a significantly better CI in comparison to other FIF plans (p< 0.001). Conventional-FIF (C-FIF) was the most homogeneous plan compared to all other FIF plans and SW-IMRT (p≤0.001). The absolute volume of small intestine that received ≥45 Gy (V45) and doses received by a 30% volume of rectum (D30) were dramatically reduced in SW-IMRT (p < 0.001). Conclusion: MLC margins had a substantial influence on OAR doses, HI and CI. A close proximity of CIOPT to 1 indicated that this formulation of CI was a useful plan evaluation tool, which was also compatible with the RTOG 1993 and ICRU-62
应用符合性指数新方法对癌症子宫内膜患者进行现场和滑动窗IMRT的剂量评估
背景:本研究的目的是评价场内场(field-in-field, FIF)和滑动窗调强放疗(sww - imrt)治疗方案在子宫内膜癌患者危险器官(OAR)的均匀性指数(HI)、符合性指数(CI)和正常组织剂量方面的差异,并得出CI的新表达。材料与方法:对20例子宫内膜癌患者行28次50.4 Gy辅助盆腔放疗的患者进行4种不同MLC(多叶准直器)边缘的FIF方案和SW-IMRT方案进行比较。通过剂量体积直方图(DVHs)评估正常组织剂量的OAR。HI和CI值根据国际放射单位和测量委员会(ICRU)-83、放射治疗肿瘤小组(RTOG) 1993和ICRU-62的报告计算。开发了一种新的CI,并将其命名为CIOPT,即优化合格指数。结果:与其他FIF计划相比,SW-IMRT提供了明显更好的CI (p< 0.001)。与所有其他FIF计划和SW-IMRT相比,常规FIF (C-FIF)是最均匀的计划(p≤0.001)。在SW-IMRT中,接受≥45 Gy (V45)和30%直肠剂量(D30)的小肠绝对体积显著减少(p < 0.001)。结论:MLC边缘对OAR剂量、HI和CI有实质性影响。CIOPT与1的接近表明,CI的这种表述是一种有用的计划评估工具,它也与RTOG 1993和ICRU-62兼容
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来源期刊
Iranian Journal of Radiation Research
Iranian Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.67
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.
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