A Narrative Review on Biopsychosocial Predictors of Cognitive Impairment among Multiple Sclerosis Patients: Directions for Malaysia Studies

Jurnal Sains Kesihatan Malaysia Pub Date : 2021-01-26 DOI:10.17576/JSKM-2021-1901-03

Chong Jia Wearn, N. C. Din, J. Joseph

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Abstract

A Narrative Review on Biopsychosocial Predictors of Cognitive Impairment among Multiple Sclerosis Patients: Directions for Malaysia Studies Chong Jia Wearn 1 , Normah Che Din 1 , Joyce Pauline Joseph 2 1 Health Psychology Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. 2 Neurology Department, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia. Abstract Cognitive impairment is the most disabling symptoms of Multiple Sclerosis (MS). Researchers have been studying factors that could predict cognitive impairment among MS patients hoping to alleviate its consequences and gather indicators of the disease progression. However, there were limited up-to-date articles that review the predictors of cognitive impairment among MS patients. In Malaysia, the topic about cognitive functioning in MS was absent. This review aims to identify and synthesize the research evidence concerning biopsychosocial variables on cognitive impairment among this population for future directions in Malaysia researches. A narrative review was performed by identifying research articles from year 2004 to 2019 through PubMed, EBSCOhost, Scopus and Google Scholar. Full-text articles meeting the selection criteria were included for qualitative synthesis. A total of 12 studies were included. Studies included in this paper found that age, course of disease and anxiety predicts cognitive functioning. Mixed results were found among variables such as gender, disability, fatigue, burden of lesion, depression and educational level. Stress was correlated with cognitive functioning but it was not a significant predictor. Although many factors were found to affect cognitive functioning among MS patients, evidence provided from this review indicates that their relationships might not be linear and direct. Keywords : predictors, cognitive impairment, multiple sclerosis, Malaysia DOI : http://dx.doi.org/10.17576/JSKM-2021-1901-03

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多发性硬化症患者认知障碍的生物心理社会预测因素述评:马来西亚研究方向

多发性硬化症患者认知障碍的生物心理社会预测因素的叙述性综述：马来西亚研究方向Chong Jia Wearn 1，Norah Che Din 1，Joyce Pauline Joseph 2 1健康心理学项目，马来西亚Kebangsaan大学健康科学学院，Jalan Raja Muda Abdul Aziz，50300，马来西亚吉隆坡。2马来西亚吉隆坡医院神经内科，邮编50586。摘要认知障碍是多发性硬化症最常见的致残症状。研究人员一直在研究可以预测多发性硬化症患者认知障碍的因素，希望减轻其后果，并收集疾病进展的指标。然而，综述多发性硬化症患者认知障碍预测因素的最新文章有限。在马来西亚，没有关于多发性硬化症认知功能的专题。本综述旨在确定和综合有关该人群认知障碍的生物心理社会变量的研究证据，为马来西亚未来的研究方向提供参考。通过PubMed、EBSCOhost、Scopus和Google Scholar对2004年至2019年的研究文章进行了叙述性综述。符合筛选标准的全文文章被纳入定性综合。共纳入12项研究。这篇论文中的研究发现，年龄、病程和焦虑可以预测认知功能。性别、残疾、疲劳、病变负担、抑郁和教育水平等变量的结果参差不齐。压力与认知功能相关，但不是一个重要的预测因素。尽管发现许多因素会影响多发性硬化症患者的认知功能，但本综述提供的证据表明，它们之间的关系可能不是线性和直接的。关键词：预测因素，认知障碍，多发性硬化症，马来西亚DOI：http://dx.doi.org/10.17576/JSKM-2021-1901-03

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Jurnal Sains Kesihatan Malaysia

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审稿时长

12 weeks