Rapid and simple CZE-UV method for quality control of B1 and B6 vitamins in drugs and dietary supplements

European Pharmaceutical Journal Pub Date : 2021-01-01 DOI:10.2478/afpuc-2021-0002

M. Matušková, I. Čižmárová, P. Chaľová, P. Mikuš, J. Piešťanský

引用次数: 0

Abstract

Abstract The application of hydrodynamically closed capillary zone electrophoresis combined with convenient ultraviolet (UV) detection allows fast, simple, environmentally friendly and cost-effective analysis of ions or ionisable molecules. This technique has been used to determine two selected B vitamins (thiamine, pyridoxine) in various drug formulations. The developed method was characterised by excellent validation parameters, such as linearity, precision, accuracy, limit of detection and limit of quantification. The total time of analysis was lower than 13.5 min. The results indicate that the method is suitable for implementation in routine quality control of selected B vitamins in pharmaceutical and food samples.

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快速简便的CZE-UV法用于药物和膳食补充剂中B1和B6维生素的质量控制

摘要流体动力学封闭毛细管区带电泳与方便的紫外线（UV）检测相结合的应用，可以快速、简单、环保且经济高效地分析离子或电离分子。该技术已被用于测定各种药物制剂中两种选定的B族维生素（硫胺素、吡哆醇）。所开发的方法具有良好的验证参数，如线性、精密度、准确度、检测限和定量限。分析总时间小于13.5分钟。结果表明，该方法适用于药品和食品样品中所选B族维生素的常规质量控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.