Canine mammary carcinoma: current therapeutic targets and future perspectives – a review

IF 1.8 4区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Annals of Animal Science Pub Date : 2023-02-07 DOI:10.2478/aoas-2022-0085

Muhammad Luqman Nordin, Ahmad Khusairi Azemi, N. Ismail, A. H. Nordin, W. Nabgan, Nur Amalina Noralidin, R. Shaari, Nur Zul Izzati Mohd Rajdi, M. Reduan, H. N. Siti, A. H. Rasool, N. N. I. N. Ibrahim

{"title":"Canine mammary carcinoma: current therapeutic targets and future perspectives – a review","authors":"Muhammad Luqman Nordin, Ahmad Khusairi Azemi, N. Ismail, A. H. Nordin, W. Nabgan, Nur Amalina Noralidin, R. Shaari, Nur Zul Izzati Mohd Rajdi, M. Reduan, H. N. Siti, A. H. Rasool, N. N. I. N. Ibrahim","doi":"10.2478/aoas-2022-0085","DOIUrl":null,"url":null,"abstract":"Abstract Canine mammary carcinoma (CMC) is the most common neoplasm in bitches, and it shares many biological similarities with breast cancer in humans. Drug resistance, high epigenetic mutations, and relapse rates are among the challenges which eventually urge the need for a veterinary oncologist to discover new therapeutic approaches that are more effective and safer. Therefore, in this review, we also cover the current therapeutic strategies from human medicine for the future perspectives of tumor immunotherapy in veterinary medicine. These strategies have great potential to be employed as therapeutic or prophylactic options due to their ability to modulate a specific and potent immune response against CMC. As we acquire a better understanding of canine tumor immunology, we can move towards a brighter prognosis. Additionally, we report on the recent successful studies in breast cancer that may benefit canines as well.","PeriodicalId":8235,"journal":{"name":"Annals of Animal Science","volume":"23 1","pages":"703 - 716"},"PeriodicalIF":1.8000,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Animal Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2478/aoas-2022-0085","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract Canine mammary carcinoma (CMC) is the most common neoplasm in bitches, and it shares many biological similarities with breast cancer in humans. Drug resistance, high epigenetic mutations, and relapse rates are among the challenges which eventually urge the need for a veterinary oncologist to discover new therapeutic approaches that are more effective and safer. Therefore, in this review, we also cover the current therapeutic strategies from human medicine for the future perspectives of tumor immunotherapy in veterinary medicine. These strategies have great potential to be employed as therapeutic or prophylactic options due to their ability to modulate a specific and potent immune response against CMC. As we acquire a better understanding of canine tumor immunology, we can move towards a brighter prognosis. Additionally, we report on the recent successful studies in breast cancer that may benefit canines as well.

查看原文本刊更多论文

犬乳腺癌：目前的治疗靶点和未来展望——综述

摘要犬乳腺癌（CMC）是母犬最常见的肿瘤，与人类癌症在生物学上有许多相似之处。耐药性、高表观遗传突变和复发率是最终促使兽医肿瘤学家发现更有效、更安全的新治疗方法的挑战之一。因此，在这篇综述中，我们还涵盖了当前人类医学的治疗策略，以及兽医肿瘤免疫治疗的未来前景。这些策略具有巨大的潜力，可作为治疗或预防选择，因为它们能够调节针对CMC的特异性和强效免疫反应。随着我们对犬肿瘤免疫学有了更好的了解，我们可以朝着更光明的预后迈进。此外，我们报告了最近在乳腺癌症方面的成功研究，这些研究也可能对犬科动物有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Animal Science 农林科学-奶制品与动物科学

CiteScore

4.00

自引率

5.30%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Annals of Animal Science accepts original papers and reviews from the different topics of animal science: genetic and farm animal breeding, the biology, physiology and reproduction of animals, animal nutrition and feedstuffs, environment, hygiene and animal production technology, quality of animal origin products, economics and the organization of animal production.