Is Low-Flow Anesthesia with Sevoflurane Safe? An Interactive Discussion

Abstract

Administration of sevoflurane at low-flow rates is a practice that remains contested amongst anesthesiologists. To some, low-flow rates are advocated as safe, environmentally friendly, and cost-effective. Others remain adherent to the practice of higher-flow rates due to the concerns of Compound A and renal injury. In this episode of the Depth of Anesthesia podcast, we explore the claims that low-flow (< 2 L/min) administration of sevoflurane produces Compound A, and that Compound A exposure leads to renal injury. We also investigate the origins of the claims in addition to conflicting recommendations by manufacturers and regulatory agencies. The original podcast soundtrack is available on the Depth of Anesthesia website (https:// depthofanesthesia.com/24-is-low-flow-anesthesia-with-sevoflurane-safe/) and on all major podcast platforms.