Using quantitative computed tomography to predict mortality in patients with interstitial lung disease related to systemic sclerosis: implications for personalized medicine

IF 1 Q4 PHARMACOLOGY & PHARMACY
A. Ariani, N. Sverzellati, Andrea Becciolni, G. Milanese, Mario Silva
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引用次数: 1

Abstract

ABSTRACT Introduction: Interstitial lung disease (ILD) is the main cause of mortality in systemic sclerosis (SSc). Methods stratifying the prognosis of SSc-ILD are lacking in clinical practice. The quantification of ILD provides a paramount contribution to establishing prognosis and may assist in tailored treatment. Areas covered: In this review, we provide an overview of the main quantitative methods implemented in SSc-ILD (semi-quantitative assessment, volumetric, parametric, and textural quantitative evaluation). Even if they are different one from another, all of them have a prognostic value as they predict mortality as well as radiological and functional worsening. Expert opinion: Semi-quantitative rating of CT images (sQCT) is now the gold standard for SSc-ILD patient assessment and stratification. Furthermore, there are many software available for quantification objective quantification, and classification of ILD. These tools are barely burdened by inter- intra-reader variability and they are suitable for both trial and clinical application. It is therefore expected that in the next few years a better stratification of patients will be achieved by these tools, allowing to recognize patients with the worst prognosis. This, together with the availability of different treatments for pulmonary fibrosis, makes it possible to develop precision medicine also in the field of SSc-ILD.
使用定量计算机断层扫描预测与系统性硬化相关的间质性肺病患者的死亡率:对个性化药物的启示
摘要:间质性肺疾病(ILD)是系统性硬化症(SSc)患者死亡的主要原因。临床缺乏对SSc-ILD预后进行分层的方法。ILD的量化对确定预后有重要贡献,并可能有助于量身定制的治疗。涵盖领域:在这篇综述中,我们提供了SSc-ILD实施的主要定量方法的概述(半定量评估,体积,参数和纹理定量评估)。即使它们彼此不同,但它们都具有预测价值,因为它们可以预测死亡率以及放射学和功能恶化。专家意见:CT图像的半定量评分(sQCT)现在是SSc-ILD患者评估和分层的金标准。此外,有许多软件可用于量化、客观量化和ILD分类。这些工具几乎不受阅读器内部变异的影响,它们适用于试验和临床应用。因此,预计在未来几年内,这些工具将实现更好的患者分层,从而识别预后最差的患者。这一点,再加上肺纤维化的不同治疗方法的可用性,使得在SSc-ILD领域开发精准医学成为可能。
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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
9
期刊介绍: Expert Review of Precision Medicine and Drug Development publishes primarily review articles covering the development and clinical application of medicine to be used in a personalized therapy setting; in addition, the journal also publishes original research and commentary-style articles. In an era where medicine is recognizing that a one-size-fits-all approach is not always appropriate, it has become necessary to identify patients responsive to treatments and treat patient populations using a tailored approach. Areas covered include: Development and application of drugs targeted to specific genotypes and populations, as well as advanced diagnostic technologies and significant biomarkers that aid in this. Clinical trials and case studies within personalized therapy and drug development. Screening, prediction and prevention of disease, prediction of adverse events, treatment monitoring, effects of metabolomics and microbiomics on treatment. Secondary population research, genome-wide association studies, disease–gene association studies, personal genome technologies. Ethical and cost–benefit issues, the impact to healthcare and business infrastructure, and regulatory issues.
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