NOTCH and tumor necrosis factor-alpha converting enzyme levels could be used in COVID-19 for risk stratification

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Indian Journal of Medical Specialities Pub Date : 2022-10-01 DOI:10.4103/injms.injms_52_22

Dilay Karabulut, G. Erdal, C. Yıldız, G. Hergünsel, Umut Karabulut, Elif Binboğa, N. Isiksacan

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引用次数: 0

Abstract

Background: Novel coronavirus disease-2019 (COVID-19) has become a public emergency that is characterized by a dysregulated immune response and hypercoagulable state. The purpose of the present study was to evaluate NOTCH and tumor necrosis factor-alpha converting enzyme (TACE) levels in COVID-19-infected patients and assess their predictive value on the severity of the disease. Methods: A total of 116 severe-critical COVID-19 patients who were interned intensive care were included in the study. The severity of the disease was evaluated according to the WHO classification system. Patients were divided into two groups according to their cTroponin T (cTnT) levels. Patients who had cTnT levels at least five times the upper limit of normal constituted Group 1 (n = 58); patients who had normal cTnT levels constituted Group 2 (n = 58). Besides, 62 age- and sex-matched healthy controls, who applied to cardiology outward clinic were taken as a control group (Group 3). All patients underwent echocardiographic examination. NOTCH and TACE levels were assessed using enzyme-linked immunosorbent assay. Results: The average age of the patients was 59.96 ± 15.46 years, 92 (51.7%) were female and 86 (48.3%) were male. The mean length of hospital stay was 16.35 ± 10.97 days. NOTCH levels were significantly higher in Group 1 patients compared to Group 2 and control group of patients P = 0.001). NOTCH levels of Group 2 were significantly higher compared to the control group (P = 0.002). Similarly, the TACE levels of Group 1 were significantly higher than that of Group 2 and the control group (P = 0.001). Mortality and length of hospital stay were significantly higher in Group 1 patients compared to Group 2 patients (P = 0.002 and P = 0.004, respectively). TACE levels of deceased patients were significantly higher than that of live patients (P = 0.004). There was a positive relationship between the length of hospital stay and NOTCH levels in Group 1 patients (r = 0.527, P = 0.003). TACE and NOTCH levels were positively correlated with troponin levels (r = 0.627 and r = 0.671, respectively P < 0.001 for both). NOTCH value of 0.34 nmol/L and TACE value of 6.53 μg/mL predicted inhospital mortality with a sensitivity of 90.30% and 63.6% and specificity of 91.5% and 78.6%, respectively. Conclusion: Measurement of NOTCH and TACE levels during severe acute respiratory syndrome coronavirus infection could be helpful for risk stratification.

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NOTCH和肿瘤坏死因子- α转换酶水平可用于COVID-19的风险分层

背景：新型冠状病毒病2019（新冠肺炎）已成为一种以免疫反应失调和高凝状态为特征的突发公共事件。本研究的目的是评估COVID-19感染患者的NOTCH和肿瘤坏死因子-α转化酶（TACE）水平，并评估其对疾病严重程度的预测价值。方法：共有116名重症新冠肺炎住院重症监护患者参与研究。根据世界卫生组织分类系统对疾病的严重程度进行评估。根据患者的肌钙蛋白T（cTnT）水平将患者分为两组。cTnT水平至少为正常上限五倍的患者构成第1组（n=58）；cTnT水平正常的患者构成第2组（n=58）。此外，将62名年龄和性别匹配的健康对照者作为对照组（第3组），他们申请到心脏病学门诊。所有患者均接受了超声心动图检查。NOTCH和TACE水平采用酶联免疫吸附测定法进行评估。结果：患者平均年龄59.96±15.46岁，女性92例（51.7%），男性86例（48.3%）。平均住院时间为16.35±10.97天。与第2组和对照组患者相比，第1组患者的NOTCH水平显著升高（P=0.001）。与对照组相比，第2组患者的NOTCH水平显著较高（P=0.002）。同样，1组TACE水平显著高于2组和对照组（P=0.001）。1组患者的死亡率和住院时间明显高于2组（分别为P=0.002和P=0.004）。死亡患者的TACE水平显著高于活着的患者（P=0.004）。第1组患者的住院时间与NOTCH水平呈正相关（r=0.527，P=0.003）。TACE和NOTCH水平与肌钙蛋白水平呈正相关。NOTCH值为0.34nmol/L，TACE值为6.53μg/mL，预测住院死亡率的敏感性分别为90.30%和63.6%，特异性分别为91.5%和78.6%。结论：在严重急性呼吸综合征冠状病毒感染期间测量NOTCH和TACE水平有助于风险分层。

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来源期刊

Indian Journal of Medical Specialities MEDICINE, GENERAL & INTERNAL-

自引率

16.70%

发文量

期刊介绍： The Indian Journal of Medical Specialities is an all-encompassing peer-reviewed quarterly journal. The journal publishes scholarly articles, reviews, case reports and original research papers from medical specialities specially pertaining to clinical patterns and epidemiological profile of diseases. An important highlight is the emphasis on undergraduate and postgraduate medical education including various aspects of scientific paper-writing. The journal gives priority to research originating from the developing world, including from the tropical regions of the world. The journal also publishes special issues on health topics of current interest. The Indian Journal of Medical Specialities is one of the very few quality multispeciality scientific medical journals.