Analysis of Nano-Silver Application in Nasosinusitis and Its Effect on Eotaxin

Abstract

Nasosinusitis (NA) is a severe inflammatory disease. In recent years, NA’s morbidity and its threat to patients is becoming increasingly serious. Clinically, it is considered that NA recurrence and refractoriness is due to eosinophil (EO) proliferation. Nanotechnology improvement and application is a breakthrough in diagnosing and treating clinical diseases. Among which, nano-silver (NNS) technology is consistent with effective NA treatment, but there is no reliable research demonstrating this. In this study, inflammatory factors, EO chemokines, and epidermal growth factors (EGF) in NNS-treated NA mice were analyzed to determine whether NNS had a potential therapeutic effect on NA. The results showed the clinical NA symptom score in mice decreased (P <0.05). Inflammatory factors in nasal lavage fluid (NLF), as well as NF-κB and eotaxin in the maxillary sinus mucosa were inhibited (P <0.05). Finally, EGF and epidermal growth factor receptor increased (P <0.05). These data demonstrate that NNS is an effective NA treatment. NNS may be able to reduce the cell inflammation occurrence and development by inhibiting EO chemokine expression, and promoting certain repair programs to the damaged nasal mucosa. There, NNS may become a feasible scheme for future NA treatment.