Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine

Q3 Medicine
A. Abu Taha, Ahmad Yaseen, S. Suleiman, Omar Abu Zenah, Hammam Ali, R. Abu Seir, Khaled Younis
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引用次数: 4

Abstract

Background. β-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal treatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of RBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter observational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study included 215 thalassemia patients who received regular blood transfusions. Clinical and transfusion records of patients were examined. Antibody screening and identification was conducted using the microcolum gel technique. Results. Two hundred fifteen patients were included in the study. More than half (52.1%) of the patients were males. The median age of patients was 18 years (range: 12–24 years). The most frequent blood group was A (40.5%). Alloantibodies were detected in 12.6% of patients. Anti-D (33.3%), anti-K (25.9%) and anti-E (14.8%) were the most commonly isolated antibodies. There was no association between age, sex, starting age of transfusion, number of transfused units, history of splenectomy and alloimmunization. Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization.
地中海贫血患者红细胞同种免疫频率和特征的研究:来自巴勒斯坦的多中心研究
背景β-地中海贫血是巴勒斯坦常见的遗传性溶血性疾病。红细胞(RBC)输注是主要的治疗方法,但它可能导致RBC同种免疫。本研究旨在确定巴勒斯坦北部省份地中海贫血患者红细胞同种免疫的流行率和特征。方法。在巴勒斯坦北部省份的地中海贫血输血中心进行了一项前瞻性多中心观察性研究。这项研究包括215名接受定期输血的地中海贫血患者。检查了患者的临床和输血记录。采用微凝胶技术进行抗体筛选和鉴定。后果215名患者被纳入研究。超过一半(52.1%)的患者是男性。患者的中位年龄为18岁 年(范围:12-24 年)。最常见的血型是A(40.5%),12.6%的患者检测到同种抗体。抗-D(33.3%)、抗K(25.9%)和抗E(14.8%)是最常见的分离抗体。年龄、性别、输血起始年龄、输血单位数、脾切除史和同种异体免疫之间没有关联。结论。抗Rh和抗K抗体在这组患者中很常见。年龄、性别、输血起始年龄、输血单位数和脾切除史不能预测同种免疫的发生。
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来源期刊
Advances in Hematology
Advances in Hematology Medicine-Hematology
CiteScore
3.30
自引率
0.00%
发文量
10
审稿时长
15 weeks
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