D-Optimal Design for a Causal Structure for Completely Randomized and Random Blocked Experiments

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-08-30 DOI:10.1155/2022/7299086

Zaher Kmail, K. Eskridge

引用次数: 0

Abstract

Most experimental design literature on causal inference focuses on establishing a causal relationship between variables, but there is no literature on how to identify a design that results in the optimal parameter estimates for a structural equation model (SEM). In this research, search algorithms are used to produce a D-optimal design for a SEM for three-stage least squares and full information maximum likelihood estimators. Then, a D-optimal design for the estimate of the model parameters of a mixed-effects SEM is obtained. The efficiency of each of the D-optimal designs for SEMs is compared with univariate optimal and uniform designs. In each case, the causal relationship changed the optimal designs dramatically and the new D-optimal designs were more efficient.

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完全随机和随机阻塞实验因果结构的d -最优设计

大多数关于因果推断的实验设计文献都集中在建立变量之间的因果关系上，但没有关于如何确定能为结构方程模型（SEM）产生最佳参数估计的设计的文献。在这项研究中，搜索算法被用于产生三阶段最小二乘和全信息最大似然估计的SEM的D最优设计。然后，获得了用于估计混合效应SEM的模型参数的D-最优设计。将SEM的每个D最优设计的效率与单变量最优和均匀设计进行比较。在每种情况下，因果关系都会极大地改变最优设计，新的D最优设计更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.