Adipose-derived stem cells and their microenvironment (Niche) in type 2 diabetes mellitus

Q1 Biochemistry, Genetics and Molecular Biology
Karina, J. Pawitan, I. Rosadi
{"title":"Adipose-derived stem cells and their microenvironment (Niche) in type 2 diabetes mellitus","authors":"Karina, J. Pawitan, I. Rosadi","doi":"10.21037/sci.2019.12.02","DOIUrl":null,"url":null,"abstract":"The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.","PeriodicalId":21938,"journal":{"name":"Stem cell investigation","volume":"7 1","pages":"2-2"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/sci.2019.12.02","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stem cell investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/sci.2019.12.02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 4

Abstract

The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.
2型糖尿病患者的脂肪干细胞及其微环境
全球2型糖尿病(T2DM)患者数量持续上升。基质血管组分(SVF)含有脂肪组织干细胞(ASCs),是一种治疗T2DM的替代疗法。T2DM通过升高血糖水平、氧化应激和缺氧来改变脂肪组织微环境(生态位),从而增加炎症的危险因素,导致微环境(生态位)的重塑,从而可能影响脂肪组织中的各种细胞,包括ASCs。因此,糖尿病可能通过其微环境影响自体SVF的质量。在这篇综述中,我们讨论了脂肪组织的主要功能,包括脂肪形成、ASCs微环境和SVF在T2DM中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Stem cell investigation
Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
5.80
自引率
0.00%
发文量
9
期刊介绍: The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信