Challenges associated with ceftriaxone resistance in Salmonella

Q1 Biochemistry, Genetics and Molecular Biology

Frontiers in Life Science Pub Date : 2018-01-01 DOI:10.1080/21553769.2018.1491427

Ayman Ahmad Al kraiem, Guang Yang, Fahd Al kraiem, Tie Chen

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引用次数: 11

Abstract

ABSTRACT Salmonella is the leading cause of typhoidal and non-typhoidal infections in the world. The entry of Salmonella into the bloodstream causes an invasive disease state, resulting to high morbidity and mortality rates, especially in children. Owing to the misuse of antibiotics, certain Salmonella serovars are multi-drug resistant and do not respond to traditional antibiotics, such as ampicillin and trimethoprim-sulphamethoxazole, presenting a significant challenge for healthcare practitioners in treating and controlling the spread of this disease. Therefore, expensive third-generation cephalosporins, such as ceftriaxone, are currently used to treat Salmonella infection. However, a novel serovar of Salmonella that resists ceftriaxone was recently identified in Saudi Arabia, indicating wide spread Salmonella resistance. A comprehensive literature review on ceftriaxone resistance in Salmonella is therefore necessary to reflect upon current challenges. In this report, we provide a summary of Salmonella incidence, mechanisms of ceftriaxone resistance in Salmonella, and current treatment options.

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沙门氏菌对头孢曲松耐药性的挑战

摘要沙门氏菌是世界上引起伤寒和非伤寒感染的主要原因。沙门氏菌进入血液会导致侵袭性疾病状态，导致高发病率和死亡率，尤其是在儿童中。由于滥用抗生素，某些沙门氏菌血清型对多种药物具有耐药性，对氨苄青霉素和甲氧苄啶-磺胺甲恶唑等传统抗生素没有反应，这给医疗从业者治疗和控制这种疾病的传播带来了重大挑战。因此，昂贵的第三代头孢菌素，如头孢曲松，目前用于治疗沙门氏菌感染。然而，最近在沙特阿拉伯发现了一种抗头孢曲松的新型沙门氏菌血清型，表明沙门氏菌的耐药性广泛传播。因此，有必要对沙门氏菌对头孢曲松的耐药性进行全面的文献综述，以反思当前的挑战。在本报告中，我们总结了沙门氏菌的发病率、沙门氏菌对头孢曲松的耐药性机制以及目前的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Life Science MULTIDISCIPLINARY SCIENCES-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Frontiers in Life Science publishes high quality and innovative research at the frontier of biology with an emphasis on interdisciplinary research. We particularly encourage manuscripts that lie at the interface of the life sciences and either the more quantitative sciences (including chemistry, physics, mathematics, and informatics) or the social sciences (philosophy, anthropology, sociology and epistemology). We believe that these various disciplines can all contribute to biological research and provide original insights to the most recurrent questions.