Analysis of blood and fecal microbiome profile in patients with celiac disease

Q1 Medicine

Human Microbiome Journal Pub Date : 2019-03-01 DOI:10.1016/j.humic.2018.12.001

Gloria Serena , Camron Davies , Murat Cetinbas , Ruslan I. Sadreyev , Alessio Fasano

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引用次数: 20

Abstract

Celiac disease is a multifactorial autoimmune enteropathy triggered by ingestion of gluten in genetically predisposed individuals. The increase of incidence in celiac disease suggests that additional environmental factors other than gluten may contribute to its onset and development. While intestinal dysbiosis has already been associated with celiac disease, the role that the blood microbiome plays in the loss of tolerance to gluten is unknown. In this study we aimed at evaluating weather celiac patients are characterized by alterations in the blood microbiome and how these changes may relate to the intestinal microbiome composition and, ultimately, to the loss of tolerance to gluten. Our data highlight alterations in the blood microbiome composition and taxonomic diversity in celiac patients as compared to healthy subjects. Although preliminary, these findings suggest that changes in the blood microbiome may contribute to the pathogenesis of celiac disease and open the possibility of new therapeutic and diagnostic tools for celiac patients.

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乳糜泻患者血液和粪便微生物组分析

乳糜泻是一种多因素的自身免疫性肠病，由遗传易感个体摄入麸质引发。乳糜泻发病率的增加表明除谷蛋白外的其他环境因素可能有助于其发病和发展。虽然肠道生态失调已经与乳糜泻有关，但血液微生物群在失去对麸质耐受性方面所起的作用尚不清楚。在这项研究中，我们旨在评估乳糜泻患者是否以血液微生物组的改变为特征，以及这些变化如何与肠道微生物组组成以及最终与对麸质耐受性的丧失有关。我们的数据强调了与健康受试者相比，乳糜泻患者血液微生物组组成和分类多样性的变化。虽然是初步的，但这些发现表明血液微生物组的变化可能与乳糜泻的发病机制有关，并为乳糜泻患者提供新的治疗和诊断工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

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期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.