Impact of Body Mass Index on the Prevalence of Metabolic Syndrome among Infertile South Indian Women

Q4 Medicine
R. Vembu, Mathivanan Nandini Devi, S. Nellepalli, M. Pandurangi, S. Nagireddy
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引用次数: 2

Abstract

To study the prevalence of metabolic syndrome (MBS) in different body mass index (BMI) group infertile women in both polycystic ovarian syndrome (PCOS) and non-PCOS subgroups. A prospective cross-sectional study of all infertile women attending the outpatient in the department of reproductive medicine and surgery in a tertiary care center catering patients from South India was conducted. These women were categorized based on BMI into groups as ≤23 kg/m2, 23.1–25 kg/m2, 25.1–27 kg/m2, 27.1–30 kg/m2, and >30 kg/m2. They were further subdivided as PCOS and non-PCOS based on Rotterdam criteria (2003). These women underwent screening for MBS according to the modified American Heart Association/National Heart Lung Blood Institute AHA/NHLBI (ATP III 2005) definition. The results were analyzed for significance by the unpaired t test and the Chi-square test. A total of 1,030 infertile women were analyzed. The mean age was 28.8 ± 4.5 years; mean BMI was 26.9 ± 3.7 kg/m2. More than 90% of women had waist circumference >80 cm. The prevalence of MBS among the infertile women was 35.3% and among PCOS and non-PCOS women was 44.7 and 28.9%, respectively. Even though there was statistically no significant difference in the metabolic parameters among PCOS and non-PCOS subgroups in different BMI cutoff levels, there was an increase in abnormal metabolic parameters with increase in BMI. The prevalence of MBS in the BMI groups among PCOS women was 11.1, 28.1, 29.7, 51.8, and 73.6%, respectively (p = 0.0005) and among non-PCOS women was 4.9, 20.4, 24.6, 41.6, and 66.7%, respectively (p = 0.0005). The BMI is an independent risk factor for MBS in both PCOS and non-PCOS infertile women. Screening for MBS in infertile women helps in early identification and primary prevention by lifestyle modification helps in delaying long-term consequences of type 2 diabetes mellitus and cardiovascular diseases. Vembu R, Nandini Devi M, Nellepalli SR, et al. Impact of Body Mass Index on the Prevalence of Metabolic Syndrome among Infertile South Indian Women. Int J Infertil Fetal Med 2019;10(3):42–45.
体重指数对南印度不孕妇女代谢综合征患病率的影响
探讨多囊卵巢综合征(PCOS)和非PCOS亚组不孕妇女代谢综合征(MBS)在不同体重指数(BMI)组的患病率。一项前瞻性横断面研究的所有不孕症妇女参加门诊生殖医学和外科在三级保健中心餐饮患者来自印度南部进行。这些女性根据BMI分为≤23 kg/m2、23.1-25 kg/m2、25.1-27 kg/m2、27.1-30 kg/m2和bb0 30 kg/m2组。根据鹿特丹标准(2003),它们进一步细分为多囊卵巢综合征和非多囊卵巢综合征。这些妇女根据修改后的美国心脏协会/国家心肺血液研究所AHA/NHLBI (ATP III 2005)定义接受MBS筛查。采用非配对t检验和卡方检验对结果进行显著性分析。总共分析了1030名不孕妇女。平均年龄28.8±4.5岁;平均BMI为26.9±3.7 kg/m2。超过90%的女性腰围为80厘米。不孕妇女中MBS患病率为35.3%,多囊卵巢综合征和非多囊卵巢综合征妇女中MBS患病率分别为44.7%和28.9%。尽管不同BMI临界值下PCOS亚组与非PCOS亚组的代谢参数差异无统计学意义,但异常代谢参数随BMI升高而增加。BMI组中PCOS女性的MBS患病率分别为11.1、28.1、29.7、51.8、73.6% (p = 0.0005),非PCOS女性的MBS患病率分别为4.9、20.4、24.6、41.6、66.7% (p = 0.0005)。BMI是多囊卵巢综合征和非多囊卵巢综合征不孕妇女发生MBS的独立危险因素。不孕妇女的MBS筛查有助于早期识别和通过改变生活方式进行初级预防,有助于延缓2型糖尿病和心血管疾病的长期后果。Vembu R, Nandini Devi M, Nellepalli SR,等。体重指数对南印度不孕妇女代谢综合征患病率的影响国际不孕胎儿医学杂志2019;10(3):42-45。
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