Gut microorganisms and neurological disease perspectives

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2021-07-13 DOI:10.2217/fnl-2020-0026

Nairita Ahsan Faruqui, Durdana Hossain Prium, Sadrina Afrin Mowna, M. Ullah, Yusha Araf, Bishajit Sarkar, U. S. Zohora, Mohammad Shahedur Rahman

引用次数: 7

Abstract

The gastrointestinal tract of every healthy human consists of a unique set of gut microbiota that collectively harbors a diverse and complex community of over 100 trillion microorganisms, including bacteria, viruses, archaea, protozoa and fungi. Gut microbes have a symbiotic relationship with our body. The composition of the microbiota is shaped early in life by gut maturation, which is influenced by several factors. Intestinal bacteria are crucial in maintaining immune and metabolic homeostasis and protecting against pathogens. Dysbiosis of gut microbiota is associated not only with intestinal disorders but also with extraintestinal diseases such as metabolic and neurological disorders. In this review, the authors examine different studies that have revealed the possible hypotheses and links in the development of neurological disorders associated with the gut microbiome.

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肠道微生物和神经系统疾病的观点

每个健康人的胃肠道都由一组独特的肠道微生物群组成，这些微生物群共同拥有超过100万亿种微生物的多样化和复杂群落，包括细菌、病毒、古生菌、原生动物和真菌。肠道微生物与我们的身体有着共生关系。微生物群的组成在生命早期由肠道成熟形成，这受到几个因素的影响。肠道细菌在维持免疫和代谢稳态以及抵御病原体方面起着至关重要的作用。肠道菌群失调不仅与肠道疾病有关，还与代谢和神经系统疾病等肠外疾病有关。在这篇综述中，作者检查了不同的研究，这些研究揭示了与肠道微生物组相关的神经系统疾病发展的可能假设和联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.