Antitumor activity of the novel pyridine derivative

Q3 Pharmacology, Toxicology and Pharmaceutics
E. Blinova, A. Epishkina, O. M. Tumutolova, O. Deryabina, S. Skachilova, Mihail Yu. Kudriavtsev, E. Shikh, O. S. Vavilova, Yulia S. Gilevskaya, G. Brykin, A. A. Makhrova, D. Blinov
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引用次数: 1

Abstract

Introduction: The study aim was to explore a toxicological property and antitumor action of the novel pyridine derivative LHT-17-19 in cell culture and on experimental models of lung cancer in mice. Materials and methods: The study was performed on male and female ICR(CD-1), male BALB/c, male BALB/c nu/nu mice. Pyridine derivative (LHT-17-19) was studied as water-soluble pharmaceutical substance. Acute toxicity was evaluated in groups of 5 animals, and the results were analyzed by Finney. Antitumor and antimetastatic activity was studied in syngeneic and xenograft models of lung cancer in mice. Results and discussion: LHT-17-19 belongs to class 3 of the toxicity classification of chemicals in accordance with GOST 12.1.007–76. The substance demonstrated an antitumor and antimetastatic property in mice with syngeneic tumor Lewis lung carcinoma as well as on the heterotopic tumor model of non-small cell lung cancer in humanized animals. Conclusion: LHT-17-19 belongs to class 3 of the toxicity classification of chemicals in accordance with WHO recommendation. LHT-17-19 exerts antitumor and antimetastatic property on both syngeneic and patient-derived lung cancer xenograft murine models. Graphical abstract
Antitumor新型吡啶衍生物的活性
简介:本研究旨在探讨新型吡啶衍生物LHT-17-19在细胞培养和小鼠癌症实验模型中的毒理学性质和抗肿瘤作用。材料和方法:采用ICR(CD-1)雄性和雌性、BALB/c雄性和BALB/c nu/nu雄性小鼠进行研究。吡啶衍生物(LHT-17-19)是一种水溶性药物。对5只动物的急性毒性进行了评估,Finney对结果进行了分析。在小鼠肺癌症同基因和异种移植模型中研究了抗肿瘤和抗转移活性。结果和讨论:根据GOST 12.1.007-76,LHT-17-19属于化学品毒性分类的第3类。该物质在患有同基因肿瘤Lewis肺癌的小鼠中以及在人源化动物的非小细胞肺癌异位肿瘤模型上显示出抗肿瘤和抗转移特性。结论:LHT-17-19属于世界卫生组织推荐的化学品毒性分类第3类。LHT-17-19对同基因和患者来源的癌症异种移植小鼠模型均具有抗肿瘤和抗转移特性。图形摘要
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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