Course of COVID-19 in patients with HIV infection and morphological changes in the lungs with a combined damage SARS-CoV2 and secondary infections

Q4 Medicine

HIV Infection and Immunosuppressive Disorders Pub Date : 2022-05-19 DOI:10.22328/2077-9828-2022-14-1-107-114

D. Kapustin, E. Krasnova, N. Khokhlova, O. M. Shishkova, Ya. S. Ulyanova, A. I. Tyryshkin

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引用次数: 1

Abstract

The purpose statement is to study the course of COVID-19 in patients with HIV infection and morphological changes in the lungs with their combined SARS-CoV-2 and secondary infections.Materials and methods: The study included 96 patients with HIV infection and SARS-CoV-2 infection confirmed by PCR, aged 26 to 54 years. The clinical manifestations, the content of CD4-lymphocytes and HIV RNA, the presence of secondary infections, and morphological changes in the lungs were studied.Results and discussion: In patients with HIV infection with moderate or severe immunodeficiency, a mild course of COVID19 (63.2%) was observed more often than in patients without immunodeficiency (14.3%). Four out of 9 patients with severe immunodeficiency developed a combined lesion of the lung tissue (SARS-CoV-2 + CMV and SARS-CoV-2 + Pneumocystis carinii) with a fatal outcome.Conclusion: In the diagnosis and treatment of COVID-19 in patients with HIV infection, it is necessary to take into account the severity of immunodeficiency and viral load.

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COVID-19在HIV感染患者的病程和肺部形态变化中合并损伤SARS-CoV2和继发感染

目的:研究HIV感染患者的COVID-19病程以及合并SARS-CoV-2和继发感染的肺部形态变化。材料与方法:本研究纳入96例经PCR确诊的HIV感染和SARS-CoV-2感染患者，年龄26 ~ 54岁。观察两组患者的临床表现、cd4淋巴细胞和HIV RNA含量、继发感染情况及肺部形态学变化。结果与讨论:在中重度免疫缺陷的HIV感染者中，轻度病程(63.2%)多于无免疫缺陷患者(14.3%)。9名严重免疫缺陷患者中有4名出现肺组织的联合病变(SARS-CoV-2 +巨细胞病毒和SARS-CoV-2 +卡氏肺囊虫)，结果致命。结论:在HIV感染患者的COVID-19诊断和治疗中，有必要考虑免疫缺陷的严重程度和病毒载量。

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来源期刊

HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.