Application of 18F-AV45 PET imaging in subtle cognitive decline and mild cognitive impairment patients

中华核医学与分子影像杂志 Pub Date : 2020-04-25 DOI:10.3760/CMA.J.CN321828-20190812-00166

Shuhua Ren, Qi Huang, Jin-Qing Hu, Donglang Jiang, Jianfei Xiao, Q. Guo, F. Xie, Fengchun Hua, Y. Guan

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引用次数: 0

Abstract

Objective To investigate the correlations between cerebral β-amyloid (Aβ) deposition assessed by 18F-florbetapir (AV45) PET imaging and clinical cognitive symptoms in patients with subtle cognitive decline (SCD) and mild cognitive impairment (MCI). Methods Data of twenty-four patients (11 males, 13 females, age: (63.2±7.6) years) diagnosed as SCD (n=15) or MCI (n=9) from December 2018 to March 2019 in Shanghai Jiao Tong University Affiliated Sixth People′s Hospital were collected prospectively. All patients underwent 18F-AV45 PET imaging, brain MRI T1 scan and Mini-Mental State Examination (MMSE) within two weeks. 18F-AV45 PET images were analyzed visually (positive, mild positive, negative). After being pretreated according to the MRI, 18F-AV45 PET images were analyzed semi-quantitatively by calculating the standardized uptake value ratio (SUVR) of Aβ deposition in 8 regions of interest (ROIs; frontal lobe, lateral parietal lobe, lateral temporal lobe, medial temporal lobe, occipital lobe, basal ganglia, posterior cingulate and precuneus), with cerebellar gray matter as the reference. Partial correlation coefficients between regional SUVRs and MMSE score were calculated. Results 18F-AV45 PET imaging showed that 16 patients with positive results and 8 patients with mild positive results. MMSE score of 24 patients was 28.2±2.0, and the SUVR was 0.93-1.87. Correlation analysis revealed that Aβ deposition in frontal cortex (r=-0.432), posterior cingulate lobe (r=-0.434) and precuneus (r=-0.418) was negatively correlated with MMSE score (all P 0.05). Conclusion 18F-AV45 PET imaging can noninvasively detect brain Aβ deposition in patients, and can effectively reflect the clinical cognitive status of patients with SCD and MCI to a certain extent. Key words: Cognition disorders; Amyloid; Positron-emission tomography

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18F-AV45 PET显像在轻度认知减退及轻度认知障碍患者中的应用

目的探讨18F-氟倍他吡（AV45）PET显像评估的轻度认知功能减退（SCD）和轻度认知功能障碍（MCI）患者大脑β-淀粉样蛋白（Aβ）沉积与临床认知症状的相关性。方法前瞻性收集2018年12月至2019年3月在上海交通大学附属第六人民医院诊断为SCD（n=15）或MCI（n=9）的24例患者（男11例，女13例，年龄：（63.2±7.6）岁）的数据。所有患者在两周内接受了18F-AV45 PET成像、脑MRI T1扫描和简易精神状态检查（MMSE）。视觉分析18F-AV45 PET图像（阳性、轻度阳性、阴性）。根据MRI预处理后，通过计算8个感兴趣区域（ROI；额叶、顶叶、颞叶外侧、颞叶内侧、枕叶、基底神经节、后扣带和楔前叶）Aβ沉积的标准化摄取值比（SUVR），对18F-AV45 PET图像进行半定量分析，以小脑灰质为参考。计算区域SUVR与MMSE评分之间的偏相关系数。结果18F-AV45 PET显像显示16例阳性，8例轻度阳性。24例患者MMSE评分为28.2±2.0，SUVR为0.93-1.87。相关分析显示，Aβ在额叶皮层（r=-0.432）、扣带回后叶（r=-0.434）和楔前叶（r=0.418）的沉积与MMSE评分呈负相关（均P＜0.05），能够在一定程度上有效反映SCD和MCI患者的临床认知状况。关键词：认知障碍；淀粉样蛋白；正电子发射断层扫描

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.