The evaluation of the microbial community of lower respiratory tracts microbiota in tuberculosis patients and healthy individuals using Metagenomics

K. Ghazvini, M. Youssefi, M. Keikha
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Abstract

The evaluation of microbial community of lower respiratory tracts microbiota in tuberculosis patients and healthy individuals using MetagenomicsAbstractMycobacterium tuberculosis is remained as global challenge which is considered as the top cause of human death in worldwide. the role of lower respiratory tracts microbiota interaction with the immune system to determining the final outcomes of infection with M. tuberculosis has gained attention in recent years. The aim of the present study was detection and comparison of microbial diversity and population community of lower respiratory tracts the microflora in pulmonary tuberculosis and healthy individuals using high throughput sequencing data by metagenomics. We found that microbial taxa were similar between TB and normal except Tenericutes which supplemented in microflora of pulmonary tuberculosis cases. Moreover, the abundance of bacterial genera is significantly divers between TB and healthy groups. Keywords: Mycobacterium tuberculosis; Microbiota; Tuberculosis; 16S rRNA; MetagenomicsAlthough it’s a century since Robert Koch introduced the Mycobacterium tuberculosis as a causative agent of tuberculosis (TB), this remains one of the leading causes of death throughout the globe (1-2). According to WHO reports in 2020, about 10 million individuals have become infected with tuberculosis, and 1.5 million have died in 2019 (3). In recent years, tuberculosis eradication seems to be impossible due to the inefficacy of the BCG vaccine in adults, the proliferation of patients with immunodeficiency, HIV pandemics, and drug-resistance TB (4-7).
应用宏基因组学评价肺结核患者和健康人群下呼吸道微生物群落
摘要结核分枝杆菌被认为是世界范围内人类死亡的头号杀手,是一个全球性的挑战。近年来,下呼吸道微生物群与免疫系统的相互作用在决定结核分枝杆菌感染的最终结局中的作用已引起人们的关注。本研究的目的是利用宏基因组学的高通量测序数据检测和比较肺结核患者和健康人群下呼吸道的微生物多样性和种群群落。结果发现,结核菌群与正常菌群基本一致,但结核菌群中有微量菌群存在。此外,结核病组和健康组之间的细菌属丰度明显不同。关键词:结核分枝杆菌;微生物群;肺结核;16 s rRNA;虽然罗伯特·科赫(Robert Koch)将结核分枝杆菌(Mycobacterium tuberculosis)作为结核病(TB)的病原体引入已有一个世纪,但它仍然是全球范围内导致死亡的主要原因之一(1-2)。根据世卫组织2020年的报告,全球约有1000万人感染结核病,2019年有150万人死亡(3)。近年来,由于成人卡介苗无效、免疫缺陷患者激增、艾滋病毒大流行和耐药结核病,结核病根除似乎是不可能的(4-7)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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