Clinical characteristics between older and younger patients with COVID-19 infection in a tertiary hospital: a retrospective cross-sectional study

Q4 Medicine

Asian Journal of Gerontology and Geriatrics Pub Date : 2023-01-12 DOI:10.12809/ajgg-2022-528-oa

Y. Ho, Ungku Ahmad Ameen bin Ungku Mohd Zam, Dewi Juita Sirimanne, A. Shunmugarajoo, Nur Asyikin bt Mohd Yunus, Azureen bt Azmel, Ai Xuan Tee, Intan Nur Hadilah, Q. Lau, Nor Nadia Farasha bt Abdullah

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引用次数: 0

Abstract

Objective. This study aims to compare older and younger patients with COVID-19 infection in terms of patient characteristics, presenting symptoms, laboratory parameters, complications, treatment received, and outcomes. Methods. Medical records of patients aged >12 years who were admitted to Hospital Tengku Ampuan Rahimah between 1 January 2021 and 31 June 2021 with polymerase chain reaction-proven COVID-19 infection were retrospectively reviewed. Data collected included sociodemographic data (age, ethnicity, sex, and residence), comorbidities, COVID-19 presentation (acute presenting symptoms, primary working diagnosis, disease severity, laboratory parameters on admission, and treatment received), and outcomes (complications, length of hospital stay, discharge destination, oxygen support required, and mortality). Results. A total of 259 patients aged 18 to 91 years were admitted to our hospital with COVID-19 infection. Of them, 182 (70.3%) were younger patients and 77 (29.7%) were older patients (aged >60 years). More older patients than younger patients had comorbidities (87.0% vs 49.5%, p<0.001) and presented with delirium (13% vs 0.5%, p<0.001) and lethargy (33.8% vs 15.9%, p=0.001). More older patients had severe COVID-19 infection (72.7% vs 38.5%, p<0.001), with 9.1% necessitating intubation. More older patients were prescribed favipiravir (64.9% vs 32.4%, p<0.001), antibiotics (76.6% vs 44%, p<0.001), and steroid (75.3% vs 40.1%, p<0.001). More older patients required intensive care (32.5% vs 17%, p=0.003). More older patients developed complications such as secondary infection (41.6% vs 17%, p<0.001) and acute kidney injury necessitating dialysis (20.8% vs 8.8%, p=0.005). Older patients had longer length of hospital stay (14 vs 12 days, p<0.001) and higher mortality (18.2% vs 4.4%, p<0.001). Conclusion. Older patients with COVID-19 infection tend to have more severe disease, higher complication rate, and higher mortality. Timely management is essential to minimise morbidity and mortality.

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三级医院中老年和年轻新冠肺炎感染患者的临床特征：回顾性横断面研究

客观的本研究旨在比较老年和年轻新冠肺炎感染患者的特征、症状、实验室参数、并发症、接受的治疗和结果。方法。回顾性审查了2021年1月1日至2021年6月31日期间因聚合酶链式反应导致新冠肺炎感染而入住腾库Ampuan Rahimah医院的12岁以上患者的医疗记录。收集的数据包括社会人口学数据（年龄、种族、性别和居住地）、合并症、新冠肺炎表现（急性表现症状、主要工作诊断、疾病严重程度、入院实验室参数和接受的治疗）和结果（并发症、住院时间、出院目的地、所需氧气支持和死亡率）。后果我院共有259名18至91岁的新冠肺炎感染患者入院。其中182例（70.3%）为年轻患者，77例（29.7%）为老年患者（年龄>60岁）。患有合并症的老年患者比年轻患者多（87.0%对49.5%，p<0.001），出现谵妄（13%对0.5%，p<0.01）和嗜睡（33.8%对15.9%，p=0.001）。患有严重新冠肺炎感染的老年患者更多（72.7%对38.5%，p>0.001），9.1%需要插管。更多的老年患者服用了法匹拉韦（64.9%对32.4%，p＜0.001）、抗生素（76.6%对44%，p＜001），和类固醇（75.3%vs 40.1%，p＜0.001）。更多的老年患者需要重症监护（32.5%vs 17%，p＝0.003）。更多老年患者出现并发症，如继发感染（41.6%vs 17%）和需要透析的急性肾损伤（20.8%vs 8.8%，p＝0.005）。老年患者住院时间更长（14天vs 12天，p＜001），死亡率更高（18.2%vs 4.4%，p＜0.005）。结论新冠肺炎感染的老年患者往往病情更严重，并发症发生率更高，死亡率更高。及时管理对于将发病率和死亡率降至最低至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Gerontology and Geriatrics Medicine-Geriatrics and Gerontology

CiteScore

0.90

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0.00%

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