{"title":"Association of VEGF polymorphisms and breast cancer susceptibility: Systemic review and meta-analysis","authors":"Y. Santhosh Kumar , Sindhu Varghese , Langeswaran Kulanthaivel , Gowtham Kumar Subbaraj","doi":"10.1016/j.mgene.2021.100946","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>This meta-analysis aimed to evaluate the association between different VEGF gene polymorphisms (VEGF 2578 C/A, VEGF 936 C/T, VEGF 634 G/C, VEGF 460 T/C and VEGF 405 C/G).</p></div><div><h3>Methodology</h3><p>Meta-analysis was performed by collecting the results of 24 appropriate studies that were retrieved from PubMed central, Embase and Google Scholar. The statistical analyses were performed by using Review Manager 5.4 software.</p></div><div><h3>Results</h3><p>The Meta analysis results revealed that there is no significant association between VEGF 2578 C/A, VEGF 460 T/C, VEGF 634 G/C, and 405 G/C gene polymorphisms with the risk of breast cancer. Additionally, a significant association was identified in VEGF 936 C/T polymorphism with risk of breast cancer. No publication bias was observed.</p></div><div><h3>Conclusion</h3><p>The results revealed that VEGF 2578 C/A, VEGF 460 T/C, VEGF 634 G/C, 405 G/C gene polymorphisms were not associated with the risk of breast cancer whereas VEGF 936 C/T polymorphism maybe associated with breast cancer. Further well deliberated studies with bigger sample size are essential to evaluate the associations.</p></div>","PeriodicalId":38190,"journal":{"name":"Meta Gene","volume":"30 ","pages":"Article 100946"},"PeriodicalIF":0.8000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mgene.2021.100946","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Meta Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214540021000979","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 3
Abstract
Aim
This meta-analysis aimed to evaluate the association between different VEGF gene polymorphisms (VEGF 2578 C/A, VEGF 936 C/T, VEGF 634 G/C, VEGF 460 T/C and VEGF 405 C/G).
Methodology
Meta-analysis was performed by collecting the results of 24 appropriate studies that were retrieved from PubMed central, Embase and Google Scholar. The statistical analyses were performed by using Review Manager 5.4 software.
Results
The Meta analysis results revealed that there is no significant association between VEGF 2578 C/A, VEGF 460 T/C, VEGF 634 G/C, and 405 G/C gene polymorphisms with the risk of breast cancer. Additionally, a significant association was identified in VEGF 936 C/T polymorphism with risk of breast cancer. No publication bias was observed.
Conclusion
The results revealed that VEGF 2578 C/A, VEGF 460 T/C, VEGF 634 G/C, 405 G/C gene polymorphisms were not associated with the risk of breast cancer whereas VEGF 936 C/T polymorphism maybe associated with breast cancer. Further well deliberated studies with bigger sample size are essential to evaluate the associations.
Meta GeneBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍:
Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.