Methylenetetrahydrofolate reductase C677T polymorphism across acute leukemia

Abstract

Background Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme for folate metabolism and also plays a role in DNA biosynthesis and the epigenetic process of DNA methylation. MTHFR gene polymorphisms, mainly the C677T, have been implicated as risk factors for several types of cancers such as the acute leukemia (AL). Main body of the abstract This study was conducted to examine the extent of the association between MTHFR C677T polymorphism and AL across a comprehensive literature of meta-analysis. Relevant English-language literature was searched and retrieved from PubMed using the terms MTHFR, the C677T polymorphism, and AL. Several parameters have been studied in the assessment of correlation between AL and the MTHFR polymorphism, such as folate intake, ethnicity, age, and sex. Nevertheless, the results are contrasting. Short conclusion Comprehensive analysis of MTHFR C677T in AL may be helpful and provide new insights for a personalized therapy based on the human genotype.