Muir-Torre Syndrome with Different Clinical Presentations

Abstract

Cancer-associated genodermatoses, such as Muir-Torre syndrome are hereditary cancer syndromes associated with distinguishing cutaneous signs. Muir-Torre syndrome is an autosomal dominant syndrome caused by mutations in the mismatch repair genes and is thought to be a subtype of Lynch syndrome1,2. It is characterized by the presence of at least one sebaceous skin tumor (adenoma, epithelioma, carcinoma or keratoacanthoma) and a visceral malignancy, in the absence of other precipitating factors3,4.