Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

JBIC Journal of Biological Inorganic Chemistry Pub Date : 2023-05-04 DOI:10.1007/s00775-023-02000-6

Xiuyang Wang, Jun Shu, Tong Ni, Chengxu Xu, Bin Xu, Xiaoqiang Liu, Kaiming Zhang, Weidong Jiang

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Abstract

Two novel bis-tridentate imidazole derivatives were conveniently synthesized using a ‘one-pot’ method. Their dinuclear (Cu₂L¹Cl₄, Cu₂L²Cl₄) and mononuclear (CuL¹Cl₂, CuL²Cl₂?H₂O) copper (II) complexes were synthesized to comparably evaluate their reactivities in the hydrolytic cleavage of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP) as a classic RNA model. Single crystals of Cu₂L¹Cl₄ and Cu₂L²Cl₄ indicate that both of them are centrosymmetric, and each central copper ion is penta-coordinated. Regarding the transesterification of HPNP, both of dinuclear ones exhibited excess one order of magnitude rate enhancement in contrast with auto-hydrolysis reaction. Under comparable conditions, dinuclear complexes displayed no more than twofold increase in activity over their mononuclear analogues, which verifies the lack of binuclear cooperation effect due to long Cu-to-Cu space.

Graphical Abstract

Abstract Image

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新型双核铜(II)配合物与双三齿咪唑衍生物诱导的RNA酯交换模型

采用“一锅法”简便地合成了两种新型双三齿咪唑衍生物。合成了双核(Cu2L1Cl4, Cu2L2Cl4)和单核(CuL1Cl2, CuL2Cl2 H2O)铜(II)配合物，比较了它们在2-羟丙基对硝基苯基磷酸(HPNP)水解裂解中的反应活性。Cu2L1Cl4和Cu2L2Cl4的单晶表明它们都是中心对称的，每个中心铜离子都是五配位的。对于HPNP的酯交换反应，两种双核反应都比自水解反应的速率提高了一个数量级。在可比条件下，双核配合物的活性比其单核类似物的活性增加不超过两倍，这证实了由于cu - cu空间长而缺乏双核合作效应。图形抽象

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来源期刊

JBIC Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.