Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Q4 Biochemistry, Genetics and Molecular Biology

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-18 DOI:10.37212/JCNOS.579145

Yusuf Karagozoglu, A. E. Parlak, N. Alayunt, S. Turkoglu, I. Yıldırım, M. Karatepe

引用次数: 0

Abstract

In this study, effects of hydroxyurea derivatives 1, 3, 4 - thiadiazole and schiff base compounds on some element levels and antioxidant enzyme activities in rat liver and on antioxidant enzyme levels that are parameters of oxidative stress were investigated. For this purpose, iron (Fe), zinc (Zn) and copper (Cu) concentrations were analyzed by using atomic absorption spectroscopy superoxide dismutase (SOD) and catalase (CAT) activities were measured by using a UV spectrophotometer. Fe, Zn and Cu concentrations in the liver of rats treated with these compounds were compared with levels of SOD and CAT statistically. As a result, the increase in the antioxidant activities of SOD and CAT metalloenzymes together with decrease in levels of Cu, Zn and Fe elements observed may suggest that the elements be bound to these enzymes.

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羟基脲衍生物处理大鼠肝脏某些元素水平与氧化应激参数的关系

本研究研究了羟基脲衍生物1,3,4 -噻二唑和希夫碱化合物对大鼠肝脏中某些元素水平和抗氧化酶活性的影响，以及对氧化应激参数抗氧化酶水平的影响。用原子吸收光谱法测定了铁(Fe)、锌(Zn)和铜(Cu)的浓度，用紫外分光光度计测定了超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活性。用这些化合物处理大鼠肝脏中Fe、Zn、Cu浓度与SOD、CAT水平进行比较，并进行统计学分析。因此，SOD和CAT金属酶抗氧化活性的增强以及Cu、Zn和Fe元素水平的降低可能表明这些元素与这些酶结合在一起。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cellular Neuroscience and Oxidative Stress Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Journal of Cellular Neuroscience and Oxidative Stress isan online journal that publishes original research articles, reviews and short reviews on themolecular basisofbiophysical,physiological and pharmacological processes thatregulate cellular function, and the control or alteration of these processesby theaction of receptors, neurotransmitters, second messengers, cation, anions,drugsor disease. Areas of particular interest are four topics. They are; 1. Ion Channels (Na+-K+Channels, Cl– channels, Ca2+channels, ADP-Ribose and metabolism of NAD+,Patch-Clamp applications) 2. Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) 3. Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD+ on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson’s and Alzheimer’s diseases) 4. Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)