Suramin.

Abstract

A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factorbeta (T GF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. T his agent also inhibits vascular endothelial growth factor (VEGF)and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) Qeios · Definition, February 7, 2020