Synthesis, Characterization, Electrochemical Properties and Antimicrobial Activity of Schiff Bases and Benzimidazoles Including Ferrocene Group and Their CoCl2 Complexes

IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY

Jordan Journal of Chemistry Pub Date : 2022-04-01 DOI:10.47014/17.1.4

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引用次数: 0

Abstract

In this study, two Schiff bases, 2-(ferrocen-1-yl-methyliden)amino-4-methylphenol (HSB1) and 2-(ferrocen-1-yl-methyliden)amino-4-chloro-5-nitrophenol (HSB2), and three benzimidazole derivatives containing the ferrocene group, 2-[(ferrocen-1-yl)-5-x-6-y-1H-benzimidazole ({x = methyl, y = H} BZ1, {x = methyl, y = methyl} BZ2 and {x = chloro, y = nitro} BZ3), and their CoCl2 complexes were synthesized and characterized. Magnetic moment and molar conductivity properties of the complexes were measured. Electrochemical data obtained by cyclic voltammetry exhibits quasi-reversible one-electron redox behavior for the ligands and the complexes. In addition, antimicrobial activities of the compounds were tested against six bacteria and three fungi. It was observed that the compounds have a wide range of antimicrobial activities on the test microorganisms. It was found that the non-chelate complexes are more effective than the other complexes and ligands. The highest antifungal activity was exhibited by the Co(II) complex of BZ2 against C. parapsilosis with a MIC value of 19.5 µg/mL.

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含二茂铁基团的席夫碱和苯并咪唑及其CoCl2配合物的合成、表征、电化学性能和抗菌活性

在本研究中，两种席夫碱，2-（二茂铁-1-基亚甲基）氨基-4-甲基苯酚（HSB1）和2-（二铁-1-基亚甲基）氨基-4-氯-5-硝基苯酚（HSB2），以及三种含有二茂铁基团的苯并咪唑衍生物，2-[（二茂铁-1-基）-5-x-6-y-1H-苯并咪唑（{x=甲基，y=H}BZ1，{x=甲酯，y=甲基}BZ2和{x=氯，y=硝基}BZ3），并对它们的CoCl2配合物进行了合成和表征。测定了配合物的磁矩和摩尔电导率。通过循环伏安法获得的电化学数据显示出配体和配合物的准可逆单电子氧化还原行为。此外，还测试了这些化合物对6种细菌和3种真菌的抗菌活性。观察到这些化合物对测试微生物具有广泛的抗菌活性。研究发现，非螯合配合物比其他配合物和配体更有效。BZ2的Co（II）配合物对副psilosis表现出最高的抗真菌活性，MIC值为19.5µg/mL。

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来源期刊

Jordan Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

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0.50

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