Effect of hypericum perforatum tea on renal histology and function

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Adil Mustafa, Moamin J. Salim, K. N. Ahmad, M. Ahmed, Azzawi M. Hadi
{"title":"Effect of hypericum perforatum tea on renal histology and function","authors":"Adil Mustafa, Moamin J. Salim, K. N. Ahmad, M. Ahmed, Azzawi M. Hadi","doi":"10.34172/jrip.2022.31942","DOIUrl":null,"url":null,"abstract":"\n Introduction:\n Hypericum perforatum consists of several biologically active compounds that may affect cell physiology. Objectives: This study attempted to estimate the effect and safety of a tea that was prepared from H. perforatum on renal histology and function. Materials and Methods: A double-blind controlled experimental trial was conducted on 25 male rats. These animals were divided into four groups. Three of them were labeled as the study groups, and each consisted of seven animals. The fourth group was labeled as the control group consisting of four animals that lived in the same environment and consumed the same food as the other groups. The animals in each study group consumed a prepared tea with a different concentration for each group. The herbal tea of H. perforatum was made as recommended by the local traditional preparation method. Doses of 3, 6, and 9 cc/kg/d were calculated and selected according to the recommendation. Each of these doses was given to each group of the experiment for four weeks mixed with water. Results: A slight increase in blood urea and serum creatinine and a decrease in serum albumin levels were noticed in the experimental groups compared to the control group. In addition, the weight of the kidneys in the study groups was more than the control group. There were microscopical changes in the renal histology that was noticed in the higher doses of H. perforatum tea. Conclusion: Higher doses of H. perforatum tea can induce damage to the renal tissue.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Renal Injury Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/jrip.2022.31942","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Hypericum perforatum consists of several biologically active compounds that may affect cell physiology. Objectives: This study attempted to estimate the effect and safety of a tea that was prepared from H. perforatum on renal histology and function. Materials and Methods: A double-blind controlled experimental trial was conducted on 25 male rats. These animals were divided into four groups. Three of them were labeled as the study groups, and each consisted of seven animals. The fourth group was labeled as the control group consisting of four animals that lived in the same environment and consumed the same food as the other groups. The animals in each study group consumed a prepared tea with a different concentration for each group. The herbal tea of H. perforatum was made as recommended by the local traditional preparation method. Doses of 3, 6, and 9 cc/kg/d were calculated and selected according to the recommendation. Each of these doses was given to each group of the experiment for four weeks mixed with water. Results: A slight increase in blood urea and serum creatinine and a decrease in serum albumin levels were noticed in the experimental groups compared to the control group. In addition, the weight of the kidneys in the study groups was more than the control group. There were microscopical changes in the renal histology that was noticed in the higher doses of H. perforatum tea. Conclusion: Higher doses of H. perforatum tea can induce damage to the renal tissue.
贯叶金丝桃茶对肾脏组织学和功能的影响
引言:贯叶金丝桃由几种可能影响细胞生理的生物活性化合物组成。目的:本研究试图评估以穿孔莲为原料制备的茶对肾脏组织学和功能的影响和安全性。材料与方法:对25只雄性大鼠进行双盲对照实验。这些动物被分成四组。其中三只被标记为研究组,每只由七只动物组成。第四组被标记为对照组,由四只动物组成,它们生活在与其他组相同的环境中,食用相同的食物。每个研究组的动物都食用了一种不同浓度的预制茶。采用当地传统的制备方法,按推荐的方法制备穿孔莲凉茶。根据建议计算和选择3、6和9 cc/kg/d的剂量。将这些剂量中的每一个与水混合给予实验的每组四周。结果:与对照组相比,实验组的血尿素和血清肌酐略有升高,血清白蛋白水平下降。此外,研究组的肾脏重量高于对照组。在较高剂量的穿孔莲茶中,肾组织学出现了显微镜下的变化。结论:高剂量穿孔莲茶可引起肾组织损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信