Potential drug-drug interactions in hospitalized patients with COVID-19.

IF 0.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Acta poloniae pharmaceutica Pub Date : 2023-06-29 DOI:10.32383/appdr/162213

Danuta Szkutnik-Fiedler, Filip Kwiatkowski, Monika Chomej, D. Kołodziej, M. Michalak, E. Grześkowiak, E. Szałek

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引用次数: 0

Abstract

Most hospitalized patients with COVID-19 require complex pharmacotherapy due to underlying diseases, and polypharmacy may significantly increase the risk of drug-drug interactions (DDIs) and, in consequence, trigger adverse effects. The aim of this study was to assess the risk of potential DDIs during hospitalization in COVID-19 patients. A retrospective analysis of pharmacotherapy in 75 patients (age, Mean±SD, 63.6±14.9) with a proven diagnosis of SARS-CoV-2 infection was conducted. The analysis included drugs administered to treat comorbidities and the COVID-19 treatment. 524 moderate and 112 major interaction cases were revealed in the analyzed COVID-19 patients, and 84% of the patients were exposed to at least one major DDI. Drugs that caused the most frequently observed DDIs include macrolides, low molecular weight heparins, glucocorticosteroids, quinolones, and antihypertensive drugs. Most COVID-19 patients have comorbidities requiring polypharmacy, which increases the risk of DDIs. Therefore, additional monitoring should be considered due to potential adverse effects, drug conversion, and deprescription.

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COVID-19住院患者的潜在药物相互作用

大多数COVID-19住院患者由于基础疾病需要复杂的药物治疗，多种药物治疗可能显著增加药物相互作用(ddi)的风险，从而引发不良反应。本研究的目的是评估COVID-19患者住院期间潜在ddi的风险。回顾性分析75例确诊为SARS-CoV-2感染的患者(年龄，Mean±SD, 63.6±14.9)的药物治疗情况。该分析包括用于治疗合并症和COVID-19治疗的药物。分析的COVID-19患者中发现中度交互作用病例524例，重度交互作用病例112例，84%的患者至少暴露于一种重度DDI。引起ddi最常见的药物包括大环内酯类药物、低分子肝素、糖皮质激素、喹诺酮类药物和降压药。大多数COVID-19患者有合并症，需要多重用药，这增加了ddi的风险。因此，由于潜在的不良反应、药物转化和取消处方，应考虑额外的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta poloniae pharmaceutica 医学-药学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.