Adiponectina plasmática en mujeres obesas y no obesas con síndrome de ovarios poliquísticos

Abstract

Objective

To determine plasma adiponectin concentrations in obese and non-obese women with polycystic ovary syndrome (PCOS).

Materials and methods

A Case control study was conducted on women with a diagnosis of PCOS and age-matched healthy controls, with regular menstruation and normal ultrasound ovaries, were selected. Participants were divided into four groups (Group A: PCOS and obese; Group B: PCOS and non-obese; Group C: obese controls, and Group D: non-obese controls) according to body mass index (obese > 30 kg/m² and non-obese < 25 kg/m²). Concentrations of sexual hormones, sex hormone-binding globulin, serum glucose, insulin, and adiponectin, were measured.

Results

Obese and non-obese women with PCOS had higher luteinising hormone, follicle stimulating hormone, androstenedione, testosterone, and insulin levels compared to women in the obese and non-obese control group, respectively (P < .0001). Women with PCOS had a significantly lower concentration of adiponectin (Group A: 8.3 ± 1.6 ng/mL and Group B: 10.1 ± 1.4 ng/mL), compared with controls (Group C: 12.1 ± 2.8 ng/mL and Group D: 14.7 ± 2.6 ng/dL; P < .0001). It was observed that adiponectin concentrations had a positive and significant association with fasting blood glucose and insulin in PCOS women (P < .05).

Conclusion

There are significant differences in plasma adiponectin concentrations between obese and non-obese women with polycystic ovary syndrome and normal controls.